Continuous structural health monitoring of a full-scale high-rise building specimen on the E-defense huge shaking table is conducted over the course of its all life such from early stage of construction to final collapse, in order to accumulate dynamic behavior of steel-moment resistant structure especially for the structural health monitoring. The main results in the paper are summarized as follows: (1) During long-term ambient vibration monitoring of the high-rise building, it is shown that the changes of the first natural frequency and story stiffness estimates are clearly detected due to the construction works or structural damages. (2) Evaluating natural frequency or story stiffness during shaking table test by four schemes, we found that these decreasing tendencies of the story stiffness by the different schemes are quite similar to each other. (3) Change of dynamic characteristics can be clearly detected after a series disaster such as strong earthquake repetition, even though only the ambient vibration records at a few measure points are used.