We have established that a cationic rhodium(I)/(R,R)-QuinoxP* complex catalyzes the highly enantioselective direct intermol. hydroacylation of ﾎｱ-substituted acrylamides with unfunctionalized aliph. aldehydes to yield the corresponding ﾎｳ-ketoamides, e.g. (+)-PhCH2CH2COCH2CHMeCONPh2, in high yields with excellent ee values. [on SciFinder(R)]
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