By the year 2020, Japan is expected to account for just 4% of people with a university-level education in G20 and OECD countries, while China and India will account for 40%. For the sake of Japan competitiveness in a global context, the universities have to produce innovation- and global-minded graduates. We suggest (1) to create a truly goal-oriented education system which supports entrepreneurship (2) to develop a design-based education system (3) to gather an innovation-centered community through dedicated spaces and (4) to change students’ mindset and behavior towards difference and risk-taking. Faculties and staff members have a major role to play in encouraging students to take risk, to think differently and to overcome their “Uncertainty Avoidance” .