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論文・著書情報
| タイトル |
| 和文: | |
| 英文: | A prospective compound screening contest identified broader inhibitors for Sirtuin 1 |
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| 著者 |
| 和文: |
千葉 峻太朗,
大上 雅史,
Anastasiia Gryniukova,
Petro Borysko,
Sergey Zozulya,
安尾 信明,
吉野 龍ノ介,
Kazuyoshi Ikeda,
Woong-Hee Shin,
Daisuke Kihara,
Mitsuo Iwadate,
Hideaki Umeyama,
Takaaki Ichikawa,
Reiji Teramoto,
Kun-Yi Hsin,
GUPTA VIPUL,
Hiroaki Kitano,
Mika Sakamoto,
Akiko Higuchi,
Nobuaki Miura,
Kei Yura,
Masahiro Mochizuki,
Chandrasekaran Ramakrishnan,
A. Mary Thangakani,
D. Velmurugan,
MARIA SILUVAY MICHAEL GROMIHA,
Itsuo Nakane,
Nanako Uchida,
Hayase Hakariya,
Modong Tan,
Hironori Nakamura,
鈴木翔吾,
Tomoki Ito,
Masahiro Kawatani,
Kentaroh Kudoh,
Sakurako Takashina,
Kazuki Yamamoto,
Yoshitaka Moriwaki,
Keita Oda,
Daisuke Kobayashi,
Tatsuya Okuno,
Shintaro Minami,
George Chikenji,
Philip Prathipati,
Chioko Nagao,
Attayeb Mohsen,
Mari Ito,
Kenji Mizuguchi,
本間 光貴,
石田 貴士,
広川 貴次,
秋山 泰,
関嶋 政和.
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| 英文: |
Shuntaro Chiba,
Masahito Ohue,
Anastasiia Gryniukova,
Petro Borysko,
Sergey Zozulya,
Nobuaki Yasuo,
Ryunosuke Yoshino,
Kazuyoshi Ikeda,
Woong-Hee Shin,
Daisuke Kihara,
Mitsuo Iwadate,
Hideaki Umeyama,
Takaaki Ichikawa,
Reiji Teramoto,
Kun-Yi Hsin,
Vipul Gupta,
Hiroaki Kitano,
Mika Sakamoto,
Akiko Higuchi,
Nobuaki Miura,
Kei Yura,
Masahiro Mochizuki,
Chandrasekaran Ramakrishnan,
A. Mary Thangakani,
D. Velmurugan,
M. Michael Gromiha,
Itsuo Nakane,
Nanako Uchida,
Hayase Hakariya,
Modong Tan,
Hironori Nakamura,
Shogo Suzuki,
Tomoki Ito,
Masahiro Kawatani,
Kentaroh Kudoh,
Sakurako Takashina,
Kazuki Yamamoto,
Yoshitaka Moriwaki,
Keita Oda,
Daisuke Kobayashi,
Tatsuya Okuno,
Shintaro Minami,
George Chikenji,
Philip Prathipati,
Chioko Nagao,
Attayeb Mohsen,
Mari Ito,
Kenji Mizuguchi,
Teruki Honma,
Takashi Ishida,
Takatsugu Hirokawa,
Yutaka Akiyama,
Masakazu Sekijima..
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| 言語 |
English |
| 掲載誌/書名 |
| 和文: | |
| 英文: | Scientific Reports |
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巻, 号, ページ
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9
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| 出版年月 |
2019年12月20日 |
| 出版者 |
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| 会議名称 |
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| 開催地 |
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| 公式リンク |
https://www.nature.com/articles/s41598-019-55069-y
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| DOI |
https://doi.org/10.1038/s41598-019-55069-y |
| アブストラクト |
Potential inhibitors of a target biomolecule, NAD-dependent deacetylase Sirtuin 1, were identified by a contest-based approach, in which participants were asked to propose a prioritized list of 400 compounds from a designated compound library containing 2.5 million compounds using in silico methods and scoring. Our aim was to identify target enzyme inhibitors and to benchmark computer-aided drug discovery methods under the same experimental conditions. Collecting compound lists derived from various methods is advantageous for aggregating compounds with structurally diversified properties compared with the use of a single method. The inhibitory action on Sirtuin 1 of approximately half of the proposed compounds was experimentally accessed. Ultimately, seven structurally diverse compounds were identified. |
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