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タイトル
和文:Mutually exclusive expression of odorant receptor transgenes. 
英文:Mutually exclusive expression of odorant receptor transgenes. 
著者
和文: Serizawa S, 石井智浩, Nakatani H, Akio Tsuboi, Nagawa F, Asano M, Sudo K, Sakagami J, Sakano H, Ijiri T, Matsuda Y, Suzuki M, Yamamori T, yoichiro iwakura, Sakano H.  
英文: Serizawa S, Ishii T, Nakatani H, Akio Tsuboi, Nagawa F, Asano M, Sudo K, Sakagami J, Sakano H, Ijiri T, Matsuda Y, Suzuki M, Yamamori T, yoichiro iwakura, Sakano H.  
言語 English 
掲載誌/書名
和文:Nature neuroscience 
英文:Nature neuroscience 
巻, 号, ページ        
出版年月 2000年7月1日 
出版者
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英文: 
会議名称
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開催地
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英文: 
公式リンク https://doi.org/10.1038/76641
 
DOI https://doi.org/10.1038/76641
アブストラクト To study the mutually exclusive expression of odorant receptor (OR) genes, we generated transgenic mice that carried the murine OR gene MOR28. Expression of the transgene and the endogenous MOR28 was distinguished by using two different markers, beta-galactosidase and green fluorescent protein (GFP), respectively. Double staining of the olfactory epithelium revealed that the two genes were rarely expressed simultaneously in individual olfactory neurons. A similar exclusion was also observed between differently tagged but identical transgenes integrated into the same locus of one particular chromosome. Although allelic inactivation has been reported for the choice between the maternal and paternal alleles, this is the first demonstration of mutually exclusive activation among non-allelic OR gene members with identical coding and regulatory sequences. Such an unusual mode of gene expression, monoallelic and mutually exclusive, has previously been shown only for the antigen-receptor genes of the immune system.

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