Large floods occurred frequently in the upper Ping River basin and their potential damages are increasing due to the growth of cities and economical activities. Therefore, the information for flood protection is needed to reduce the damages, especially for city areas. This study attempts to establish a model to simulate flood and inundation against extreme rainfalls in the upper Ping River basin in Thailand for analyzing causal factors of inundation and proposing countermeasures. CASC2D model, a two dimensional hydrologic model was applied for this purpose. The model was calibrated and verified with flood discharge and inundated areas observed during the devastating floods in 2011. The simulation results were evaluated using two indices: Nash-Sutcliffe efficiency (NSE) and coefficient of determination (r2) to show acceptable model performance. The model performance of inundated areas was improved by modifying topographic conditions. It showed predicted areas of local inundation along rivers and in the agricultural fields after storm events.