"Bo Zhu,Yukihiko Yamasaki,Takanobu Yasuda,Cheng Qian,Zhirou Qiu,Mitsue Nagamine,Hiroshi Ueda,Tetsuya Kitaguchi","Customizable OpenGUS immunoassay: A homogeneous detection system using β-glucuronidase switch and label-free antibody",,"Biosensors and Bioelectronics",," 267",," 116796",2024,Sept. "Bo Zhu,Yukihiko Yamasaki,Takanobu Yasuda,Cheng Qian,Zhirou Qiu,Hiroshi Ueda,Tetsuya Kitaguchi","A one-pot detection system using β-glucuronidase-based enzyme switch and label-free antibody","The Joint Congress of 21st International Union for Pure and Applied Biophysics","The Joint Congress of 21st International Union for Pure and Applied Biophysics",,,,,2024,June "Takanobu Yasuda,Bo Zhu,Hiroshi Ueda,Tetsuya Kitaguchi","A bioluminescent immunosensor based on “Trap & Release” of luciferase-derived peptide fused to antibody","The Joint Congress of 21st International Union for Pure and Applied Biophysics","The Joint Congress of 21st International Union for Pure and Applied Biophysics",,,,,2024,June "Cheng Qian,Ayumu Ninomiya,Natsuki Shibukawa,Hiroshi Ueda,Takanobu Yasuda,Bo Zhu,Tetsuya Kitaguchi","PMBiT: A bioluminescent probe for large antigen detection","The Joint Congress of 21st International Union for Pure and Applied Biophysics","The Joint Congress of 21st International Union for Pure and Applied Biophysics",,,,,2024,June "Yinghui Yang,Akihito Inoue,Takanobu Yasuda,Hiroshi Ueda,Bo Zhu,Tetsuya Kitaguchi","Fabrication of a nanobody-based ratiometric bioluminescent immunosensor for point-of-care testing","The Joint Congress of 21st International Union for Pure and Applied Biophysics","The Joint Congress of 21st International Union for Pure and Applied Biophysics",,,,,2024,June "Yinghui Yang,Akihito Inoue,Takanobu Yasuda,Hiroshi Ueda,Bo Zhu,Tetsuya Kitaguchi","BRET nano Q-body: a nanobody-based ratiometric bioluminescent immunosensor for point-of-care testing",,"Jxiv",,,,,2024,June "安田 貴信,朱 博,上田 宏,北口 哲也","発光酵素断片のトラップ&リリースに基づく抗原検出法","化学工学会第89年会","化学工学会第89年会 要旨集",,,,,2024,Mar. "朱博,安田貴信,北口哲也","切らずに開く酵素スイッチ",,"日本化学会バイオテクノロジー部ニュースレター",,"Vol. 27","No. 2","Page 3-11",2024,Mar. "Bo Zhu,Yukihiko Yamasaki,Takanobu Yasuda,Cheng Qian,Zhirou Qiu,Hiroshi Ueda,Tetsuya Kitaguchi","A customizable one-pot detection system using β-glucuronidase switch and label-free antibody","化学工学会第89年会","化学工学会第89年会 要旨集",,,,,2024,Mar. "小野義光,有坂亮汰,二宮歩武,柴田貴広,内田浩二,安田貴信,朱博,董金華,上田宏,北口哲也","ゲノム編集によるオープンサンドイッチ免疫測定用抗体の構築と均一測定系への展開","化学工学会第89年会","化学工学会第89年会 要旨集",,,,,2024,Mar. "Li Tian,Keisuke Yamashita,Takanobu Yasuda,Takashi Tsuboi,Bo Zhu,Hiroshi Ueda,Tetsuya Kitaguchi","Single fluorescent protein-based biosensor for monitoring Intracellular IP3 dynamics",,"化学工学会第89年会 要旨集",,,,,2024,Mar. "前田侑也,安田貴信,小野田晃","トリアゾールカルボアルデヒド基により蛍光色素をN末端に修飾した抗体の調製","日本化学会第104春季年会",,,,,,2024,Mar. "渋川 夏希,笹本 佳那,瀬尾 秀宗,安田 貴信,朱 博,太田 邦史,上田 宏,北口 哲也","バイオセンサーに変換可能な抗体の取得に向けた蛍光プローブタンパク質の開発","化学工学会第89年会","化学工学会第89年会 要旨集",,,,,2024,Mar. "井上暁人,朱博,安田貴信,水谷圭佑,小林健,北口哲也","タンパク質言語モデルを用いた一変異効果予測による蛍光免疫センサーの機能向上","化学工学会第89年会","化学工学会第89年会 要旨集",,,,,2024,Mar. "笹本佳那,安田貴信,朱博,上田宏,北口哲也","順平行コイルドコイルペプチド型蛍光プローブによる蛍光免疫センサの応答向上",,"第12回日本生物工学会東日本支部コロキウム 要旨集",,,,,2024,Feb. "安田貴信,北口哲也","互いに引き合う螺旋状ペプチド ?二量体形成から細胞療法まで?",,"アグリバイオ","北隆館","vol. 8","No. 1","pp. 85-91",2024,Jan. "安田貴信,朱博,上田宏,北口哲也","生物発光免疫センサーの発光活性増大機構の解明とその原理の 全長抗体への展開","第2回日本抗体学会学術大会","第2回日本抗体学会学術大会要旨集",,,,,2023,Dec. "Zixu Feng,相原寛史,桜庭俊,Yanyan Hou,吉田啓亮,安田貴信,Bo Zhu,上田宏,伊藤寿朗,北口哲也","生細胞イメージングに適用可能なジベレリン蛍光免疫センサーへの改良","第2回日本抗体学会学術大会","第2回日本抗体学会学術大会要旨集",,,,,2023,Dec. "井上暁人,安田貴信,大内将司,北口哲也","ウサギ抗体を用いたクエンチ型cAMP蛍光免疫センサーの開発","第2回日本抗体学会学術大会","第2回日本抗体学会学術大会要旨集",,,,,2023,Dec. "Kana Sasamoto,Takanobu Yasuda,Bo Zhu,Hiroshi Ueda,Tetsuya Kitaguchi","Efficient and rapid linker optimization with heterodimeric coiled coils improves the response of fluorescent biosensors comprising antibody and protein M",,"The Analyst",,"vol. 148",,"p. 5843-5850",2023,Oct. "Bo Zhu,Yukihiko Yamasaki,Takanobu Yasuda,Cheng Qian,Zhirou Qiu,Hiroshi Ueda,Tetsuya Kitaguchi","Customizable OpenGUS immunoassay: a homogeneous detection system using split β-glucuronidase and label-free antibody",,"Jxiv",,,,,2023,Sept. "Yinghui Yang,Akihito Inoue,Takanobu Yasuda,Bo Zhu,Hiroshi Ueda,Tetsuya Kitaguchi","Fabrication of Nanobody-based Ratiometric Bioluminescent Quenchbody for Simple and Rapid Detection",,"第75回日本生物工学会大会 要旨集",,,,,2023,Sept. "二宮歩武,Qian Cheng,安田貴信,朱博,北口哲也","抗原抗体反応が抗体結合タンパク質によって阻害されることを利用した免疫センサーの開発",,"第75回日本生物工学会大会 要旨集",,,,,2023,Sept. "安田貴信,朱博,上田宏,北口哲也","抗体結合タンパク質を利用した全長抗体の生物発光センサー化","化学工学会第54回秋季大会","化学工学会第54回秋季大会要旨集",,,,,2023,Aug. "安田 貴信,北口哲也","互いに引き合う螺旋状ペプチド : 二量体形成から細胞療法まで",,"月刊細胞","北隆館","Vol. 55","No. 9","pp. 749-753",2023,July "安田 貴信,大森 健太,上田宏,北口哲也","トラップ&リリースが拓いた免疫センサーの道と抗体薬物複合体の未来",,"生物工学会誌","公益社団法人 日本生物工学会","Vol. 101","No. 6","pp. 277-280",2023,June "Akihito Inoue,Takanobu Yasuda,Tetsuya Kitaguchi,Akikazu Murakami,Hiroshi Ueda.","Selection and Trp-mutation evolution of a nanobody-based fluorescent immunosensor "nano Q-body" by yeast surface display","33rd Anniversary World Congress on Biosensors","33rd Anniversary World Congress on Biosensors",,,,,2023,June "Kana Sasamoto,Takanobu Yasuda,Tetsuya Kitaguchi,Hiroshi Ueda","Development of “Coiled Q-probe” that can effectively convert antibodies into fluorescent immunosensors","33rd Anniversary World Congress on Biosensors","33rd Anniversary World Congress on Biosensors",,,,,2023,June "Yoshihiro Ito,Ryuichi Sasaki,Sayaka Asari,Takanobu Yasuda,Hiroshi Ueda,Tetsuya Kitaguchi","Efficient Microfluidic Screening Method Using a Fluorescent Immunosensor for Recombinant Protein Secretions",,"Small",,"Volume 19","Issue 34"," 2207943",2023,Apr. "井上暁人,安田貴信,朱博,北口哲也,村上明一,上田宏","酵母細胞表層提示系を用いたナノ抗体由来”nano Q-body”のTrp変異進化","化学工学会第88年会","化学工学会第88年会要旨集",,,,,2023,Mar. "佐藤 里杏人,安田 貴信,朱 博,北口 哲也,加藤 直洋,上田 宏","3分割ルシフェラーゼを用いた免疫測定法における相互作用の測定と数理モデルの作製","化学工学会第88年会","化学工学会第88年会要旨集",,,,,2023,Mar. "Jiulong Su,Bo Zhu,Akihito Inoue,Hiroyuki Oyama,Izumi Morita,Jinhua Dong,Takanobu Yasuda,Yoshiko Sugita-Konishi,Tetsuya Kitaguchi,Norihiro Kobayashi,Shiro Miyake,Hiroshi Ueda","The Patrol Yeast: a new biosensor armed with antibody-receptor chimera detecting a range of toxic substances associated with food poisoning",,"Biosensors and Bioelectronics","Elsevier","Vol. 219",," 114793",2023,Jan. "井上暁人,安田貴信,北口哲也,村上明一,上田宏","酵母提示系によるナノ抗体由来の蛍光免疫センサnano Q-bodyの分子進化法の開発","第95回日本生化学会大会","第95回日本生化学会大会要旨集",,,,,2022,Nov. "笹本佳那,安田貴信,北口哲也,上田宏","逆並行結合抑制型ペプチドペアによる抗体を蛍光免疫センサに変換するプローブタンパク質Coiled Q-probeの蛍光応答向上","第95回日本生化学会大会","第95回日本生化学会大会要旨集",,,,,2022,Nov. "安田貴信,笹本佳那,北口哲也,上田宏","逆平行結合抑制ペプチドペアを用いたクエンチ抗体の構築と評価","第16回バイオ関連化学シンポジウム","第16回バイオ関連化学シンポジウム要旨集",,,,,2022,Sept. "井上暁人,鈴木大凱,YANG Yinghui,安田貴信,朱博,北口哲也,上田宏","コルチゾール認識ナノ抗体の蛍光免疫センサー化","第16回バイオ関連化学シンポジウム","第16回バイオ関連化学シンポジウム要旨集",,,,,2022,Sept. "倉田晴生,安田貴信,北口哲也,上田宏","発光タグを付加したペプチドを用いた免疫センサーの構築","化学工学会第53回秋季大会","化学工学会第53 回秋季大会要旨集",,,,,2022,Sept. "安田貴信","高性能な蛍光・発光免疫センサー創出のための分子設計とその解析",,,,,,,2022,Mar. "椿凜果,安田貴信,朱博,北口哲也,上田宏","蛍光免疫センサーCoiled Quenchbodyのがん光線力学療法への応用","化学工学会第87年会","化学工学会第87年会要旨集",,,,,2022,Mar. "安田貴信","高性能な蛍光・発光免疫センサー創出のための分子設計とその解析",,,,,,,2022,Mar. "安田貴信","高性能な蛍光・発光免疫センサー創出のための分子設計とその解析",,,,,,,2022,Mar. "安田貴信","高性能な蛍光・発光免疫センサー創出のための分子設計とその解析",,,,,,,2022,Mar. "Yinghui Yang,Akihito Inoue,Takanobu Yasuda,Tetsuya Kitaguchi,Hiroshi Ueda","Fabrication of BRET Q-body Using Various Antibody Fragments",,"第10回日本生物工学会東日本支部コロキウム 要旨集",,,,,2022,Mar. "安田貴信,上野慶行,栃尾尚哉,八木宏昌,北口哲也,木川隆則,上田宏","NMRによる新規免疫センサーHibodyの抗原結合に伴う発光活性増大機構の解明","第44回日本分子生物学会年会","第44回日本分子生物学会年会要旨集",,,,,2021,Dec. "Akihito Inoue,Takanobu Yasuda,Bo Zhu,Tetsuya Kitaguchi,Akikazu Murakami,Hiroshi Ueda","Evaluation and selection of potent fluorescent immunosensors by combining fluorescent peptide and nanobodies displayed on yeast surface",,"Scientific Reports","Springer Nature","Vol. 11",,"p. 22590",2021,Nov. "安田貴信,井上暁人,北口哲也,上田宏","レシオ計測が可能な蛍光免疫センサーFRET Coiled Q-bodyにおけるDonor-Acceptor間距離の検討","第94回日本生化学会大会","第94回日本生化学会大会要旨集",,,,,2021,Nov. "笹本佳那,安田貴信,北口哲也,上田宏","蛍光免疫センサープローブCoiled Q-probeを用いた各種低分子の検出と,FRET型プローブへの展開","第94回日本生化学会大会","第94回日本生化学会大会要旨集",,,,,2021,Nov. "Akihito Inoue,Takanobu Yasuda,Bo Zhu,Tetsuya Kitaguchi,Akikazu Murakami,Hiroshi Ueda.","Evaluation and selection of potent fluorescent immunosensors by combining fluorescent peptide and nanobodies displayed on yeast surface.",,"Res Sq",,,,,2021,Nov. "Yancen Dai,Atsushi Izutani,Takanobu Yasuda,Tetsuya Kitaguchi,Hiroshi Ueda","Intracellular detection of tumor suppressor protein p53 by Q-body technology","第 73回日本生物工学会大会","第 73回日本生物工学会大会要旨集",,,,,2021,Oct. "井上暁人,安田貴信,北口哲也,村上 明一,上田宏","酵母提示系を用いたナノ抗体由来の蛍光免疫センサ“mini Q-body”選択法の開発","第 73回日本生物工学会大会","第 73回日本生物工学会大会要旨集",,,,,2021,Oct. "井上暁人,安田貴信,北口哲也,村上 明一,上田宏","酵母細胞表層提示系を用いた抗ヒト血清アルブミン (HSA)ナノ抗体由来“mini Q-body”の選択","化学工学会第52回秋季大会","化学工学会第52回秋季大会要旨集",,,,,2021,Sept. "Xuerao Ning,Takanobu Yasuda,Tetsuya Kitaguchi,Hiroshi Ueda","Construction of Fluorescent Immunosensor Quenchbody to Detect His-Tagged Recombinant Proteins Produced in Bioprocess",,"Sensors","MDPI","vol. 21","Issue 15","p. 4993",2021,July "T. Yasuda,A. Inoue,T. Kitaguchi,H. Ueda","Rapid construction of fluorescence quenching-based immunosensor Q-bodies using α-helical coiled-coil peptides",,"Chemical Communications",,"vol. 57",,"p. 8206-8209",2021,July "Hiroshi Ueda,Jinhua Dong,Takanobu Yasuda,Masaki Takahashi,Kana Sasamoto,Hiroyuki Oyama,Izumi Morita,Hee-Jin Jeong,Tetsuya Kitaguchi,Norihiro Kobayashi.","PM Q-probe: a fluorescent binding protein that converts many antibodies to a fluorescent biosensor.","31st Anniversary World Congress on Biosensors",,,,,,2021,July "Riho Takahashi,Takanobu Yasuda,Yuki Ohmuro-Matsuyama,Hiroshi Ueda","BRET Q‐Body: A Ratiometric Quench-based Bioluminescent Immunosensor Made of Luciferase−Dye−Antibody Fusion with Enhanced Response",,"Analytical Chemistry",,"Vol. 93","no. 21","p. 7571-7578",2021,May "笹本佳那,安田貴信,北口哲也,上田宏","迅速簡便に高性能な蛍光免疫センサーを構築可能なCoiled Q-probeの創出","化学工学会第86年会","化学工学会第86年会要旨集",,,,,2021,Mar. "Yancen Dai,Atsushi Izutani,Takanobu Yasuda,Tetsuya Kitaguchi,Hiroshi Ueda.","Instant detection of tumor suppressor protein p53 by Q-body technology.","化学工学会第86年会","化学工学会第86年会要旨集",,,,,2021,Mar. "井上暁人,安田貴信,北口哲也,上田宏","蛍光免疫センサーQ-bodyを提示した酵母細胞の構築と抗原検出","化学工学会第51回秋季大会","化学工学会第51回秋季大会要旨集",,,,,2020,Sept. "上田宏,董金華,三宅千絢,安田貴信,?橋昌樹,大山浩之,森田いずみ,北口哲也,小林典裕","抗体を蛍光免疫センサーQ-body 化可能なタンパク質PM Q-probe による各種バイオマーカーの測定","化学工学会第51回秋季大会","化学工学会第51回秋季大会要旨集",,,,,2020,Sept. "J. Dong,C. Miyake,T. Yasuda,H. Oyama,I. Morita,T. Tsukahara,M. Takahashi,H.-J. Jeong,T. Kitaguchi,N. Kobayashi,H. Ueda","PM Q-probe: A fluorescent binding protein that converts many antibodies to a fluorescent biosensor",,"Biosensors and Bioelectronics","Elsevier","vol. 165",,"p. 112425",2020,July "Takanobu Yasuda,Akihito Inoue,Tetsuya Kitaguchi,Hiroshi Ueda.","Creation and evaluation of immunosensors that enable ratiometric assay by rapid dual-color labeling of antibody fragments.","第20回日本蛋白質科学会年会","第20回日本蛋白質科学会年会要旨集",,,,,2020,July "上田宏,安田貴信,上野慶行,井上暁人,?橋昌樹,大室有紀,北口哲也,董金華","Beyond Q-body: 色素修飾が不要な新規免疫測定素子の構築","第 71回日本生物工学会大会","第 71回日本生物工学会大会要旨集",,,,,2019,Sept. "上野慶行,安田貴信,大室有紀,北口哲也,上田宏","N末にNanoluc由来タグを持つ抗体断片は抗原依存的にNanolucの発光活性を増大させる","第19回日本蛋白質科学会年会","第19回日本蛋白質科学会年会要旨集",,,,,2019,June "安田貴信,北口哲也,上田宏","コイルドコイル形成ペプチドを利用した蛍光ラベル化法による抗体断片の迅速FRETバイオセンサー化","第19回日本蛋白質科学会年会","第19回日本蛋白質科学会年会要旨集",,,,,2019,June