@book{CTT100811738, author = {Yoshiaki Masaki and Akihiro Ohkubo and Kohji Seio and Mitsuo Sekine}, title = {Effects of 2'-O-Modifications on RNA Duplex Stability}, publisher = {Springer}, year = 2018, } @book{CTT100785543, author = {Ohkubo Akihiro and Okamoto Itaru and Kasuya Rintaro and Sakamoto Kazushi and Sasami Takeshi and Odawara Yoko and Masaki Yoshiaki and Sakaue Toshiyuki and Nagasawa Hiroshi and Tsukahara Toshifumi and Seio Kohji and Sekine Mitsuo}, title = {Protected DNA probes (PDP): A new strategy for gene detection}, publisher = {}, year = 2008, } @book{CTT100786539, author = {清尾康志 and 関根光雄}, title = {RNAの基礎知識}, publisher = {講談社サイエンティフィク}, year = 2005, } @article{CTT100785147, author = {Kaori Ando and Hisao Saneyoshi and Kohji Seio and Mitsuo Sekine}, title = {A theoretical study on the elimination reaction of acrylonitrile from 2′-O-cyanoethylated nucleosides by Bu4NF}, journal = {Tetrahedron}, year = 2019, } @article{CTT100812079, author = {Takashi Kanamori and Masaki Y and Oda Y and Ohzeki H and Ohkubo A and Sekine M and Seio K.}, title = {DNA triplex-based fluorescence turn-on sensors for adenosine using a fluorescent molecular rotor 5-(3-methylbenzofuran-2-yl) deoxyuridine}, journal = {Org. Biomol Chem.}, year = 2019, } @article{CTT100784916, author = {Yoshiaki Masaki and Keishi Yamamoto and Takeshi Inde and Keita Yoshida and Atsuya Maruyama and Tetsuya Nagata and Jun Tanihata and Shin'ichi Takeda and Mitsuo Sekine and Kohji Seio}, title = {Synthesis of 2'-O-(N-methylcarbamoylethyl) 5-methyl-2-thiouridine and its application to splice-switching oligonucleotides}, journal = {Bioorganic & Medicinal Chemistry Letters}, year = 2018, } @article{CTT100784914, author = {Yoshiaki Masaki and Yusuke Iriyama and Hiroyuki Nakajima and Yusuke Kuroda and Tatsuro Kanaki and Satoshi Furukawa and Mitsuo Sekine and Kohji Seio}, title = {Application of 2′-O-(2-N-Methylcarbamoylethyl) Nucleotides in RNase H-Dependent Antisense Oligonucleotides}, journal = {Nucleic Acid Ther.}, year = 2018, } @article{CTT100781220, author = {Takeshi Inde and Shuhei Nishizawa and Yuusaku Hattori and Takashi Kanamori and Hideya Yuasa and Kohji Seio and Mitsuo Sekine and Akihiro Ohkubo}, title = {Synthesis of and triplex formation in oligonucleotides containing 2’-deoxy-6-thioxanthosine}, journal = {}, year = 2018, } @article{CTT100784913, author = {Takahito Tomori and Kento Nagaoka and Leo Takeshita and Takashi Shiozawa and Yuya Miyatake and Yoshiaki Masaki and Mitsuo Sekine and Kohji Seio}, title = {Deoxynucleoside Triphosphate Containing Pyridazin-3-one Aglycon as a Thymidine Triphosphate Substitute for Primer Extension and Chain Elongation by Klenow fragments}, journal = {J. Org. Chem.}, year = 2018, } @article{CTT100785004, author = {K. Ohno and D. Sugiyama and L. Takeshita and T. Kanamori and Y. Masaki and M. Sekine and K. Seio}, title = {Synthesis of photocaged 6-O-(2-nitrobenzyl) guanosine and 4-O-(2-nitrobenzyl)uridine triphosphates for photocontrol of the RNA transcription reaction}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY}, year = 2017, } @article{CTT100785010, author = {T. Inde and Y. Masaki and A. Maruyama and Y. Ito and N. Makio and Y. Miyatake and T. Tomori and M. Sekine and K. Seio}, title = {Synthesis of oligonucleotides containing 2-N-heteroarylguanine residues and their effect on duplex/triplex stability}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, year = 2017, } @article{CTT100785546, author = {Masaki Yoshiaki and Sekine Mitsuo and Seio Kohji}, title = {Deformability Calculation for Estimation of the Relative Stability of Chemically Modified RNA Duplexes.}, journal = {Current protocols in nucleic acid chemistry}, year = 2017, } @article{CTT100724906, author = {Kohji Seio and Yurie Ohno and Kentaro Ohno and Leo Takeshita and Takashi Kanamori and Yoshiaki Masaki and Mitsuo Sekine}, title = {Photo-controlled binding of MutS to photo-caged DNA duplexes incorporating 4-O-(2-nitrobenzyl) or 4-O-[2-(2-nitrophenyl)propyl]thymidine}, journal = {Bioorganic & Medicinal Chemistry Letters}, year = 2016, } @article{CTT100722448, author = {Yoshiaki Masaki and Hugo Itou and Yuki Oda and Kazufumi Yamazaki and Nobuhiro Tago and Kentaro Ohno and Nozomi Ishii and Hirosuke Tsunoda and Takashi Kanamori and Akihiro Ohkubo and Mitsuo Sekine and Kohji Seio}, title = {Enzymatic synthesis and reverse transcription of RNAs incorporating 2'-O-carbamoyl uridine triphosphate}, journal = {Chemical Communications}, year = 2016, } @article{CTT100722454, author = {Munefumi Tokugawa and Yoshiaki Masaki and Jan Christian Canggadibrata and Kazuhei Kaneko and Takashi Shiozawa and Takashi Kanamori and Morten Grøtli and L. Marcus Wilhelmsson and Mitsuo Sekine and Kohji Seio}, title = {7-(Benzofuran-2-yl)-7-deazadeoxyguanosine as a fluorescence turn-ON probe for single-strand DNA binding protein}, journal = {Chemical Communications}, year = 2016, } @article{CTT100785012, author = {N. Tago and A. Katolik and N. E. Clark and E. J. Montemayor and K. Seio and M. Sekine and P. J. Hart and M. J. Damha}, title = {Design, synthesis, and properties of phosphoramidate 2 ',5 '-linked branched RNA: Toward the rational design of inhibitors of the RNA lariat debranching enzyme}, journal = {OURNAL OF ORGANIC CHEMISTRY}, year = 2015, } @article{CTT100724912, author = {Yoshiaki Masaki and Takeshi Inde and Tetsuya Nagata and Jun Tanihata and Takashi Kanamori and Kohji Seio and Shin'ichi Takeda and Mitsuo Sekine}, title = {Enhancement of exon skipping in mdx52 mice by 2′-O-methyl-2-thioribothymidine incorporation into phosphorothioate oligonucleotides}, journal = {Med. Chem. Commun.}, year = 2014, } @article{CTT100785547, author = {Masaki Yoshiaki and Yamada Takeshi and Saneyoshi Hisao and Ohkubo Akihiro and Seio Kohji and Sekine Mitsuo}, title = {Synthesis and Exon-Skipping Activity of Chemically Modified RNAs}, journal = {Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications}, year = 2014, } @article{CTT100785027, author = {Y. Masaki and R. Miyasaka and K. Hirai and T. Kanamori and H. Tsunoda and A. Ohkubo and K. Seio and M. Sekine}, title = {Properties of 5- and/or 2-modified 2 '-O-cyanoethyl uridine residue: 2 '-O-cyanoethyl-5-propynyl-2-thiouridine as an efficient duplex stabilizing component}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, year = 2014, } @article{CTT100785013, author = {T. Yamada and Y. Masaki and N. Okaniwa and T. Kanamori and A. Ohkubo and H. Tsunoda and K. Seio and M. Sekine}, title = {Synthesis and properties of oligonucleotides modified with 2 '-O-(2-carboxyethyl)nucleotides and their carbamoyl derivatives}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, year = 2014, } @article{CTT100785023, author = {K. Yamada and Y. Masaki and H. Tsunoda and A. Ohkubo and K. Seio and M. Sekine}, title = {A new modified cytosine base capable of base pairing with guanine using four hydrogen bonds}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, year = 2014, } @article{CTT100785035, author = {Y. Iijima and S. Kojima and E. Kodama and S. Kurohagi and T. Kanamori and Y. Masaki and A. Ohkubo and M. Sekine and K. Seio}, title = {Modified oligodeoxynucleotide primers for reverse-transcription of target RNAs that can discriminate among length variants at the 3 '-terminus}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, year = 2013, } @article{CTT100785032, author = {K. Seio and M. Tokugawa and H. Tsunoda and A. Ohkubo and F. Arisaka and M. Sekine}, title = {Assembly of pyrene-modified DNA/RNA duplexes incorporating a G-rich single strand region}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, year = 2013, } @article{CTT100785034, author = {A. Ohkubo and Y. Kondo and M. Suzuki and H. Kobayashi and T. Kanamori and Y. Masaki and K. Seio and K. Nagai and M. Sekine}, title = {Chemical synthesis of U1 snRNA derivatives}, journal = {ORGANIC LETTERS}, year = 2013, } @article{CTT100785029, author = {K. Yamada and A. Ohkubo and Y. Esaka and T. Kanamori and Y. Masaki and K. Seio and M. Sekine}, title = {Base recognition of gap sites in DNA-DNA and DNA-RNA duplexes by short oligonucleotides}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, year = 2013, } @article{CTT100785033, author = {K. Seio and T. Kanamori and M. Tokugawa and H. Ohzeki and Y. Masaki and H. Tsunoda and A. Ohkubo and M. Sekine}, title = {Fluorescent properties of oligonucleotides doubly modified with an indole-fused cytosine analog and 2-aminopurine}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY}, year = 2013, } @article{CTT100785031, author = {K. Yamada and Y. Hattori and T. Inde and T. Kanamori and A. Ohkubo and K. Seio and M. Sekine}, title = {Remarkable stabilization of antiparallel DNA triplexes by strong stacking effects of consecutively modified nucleobases containing thiocarbonyl groups}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, year = 2013, } @article{CTT100785037, author = {K. Seio and M. Tokugawa and T. Kanamori and H. Tsunoda and A. Ohkubo and M. Sekine}, title = {Synthesis and properties of cationic 2 '-O- N-(4-aminobutyl)carbamoyl modified oligonucleotides}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, year = 2012, } @article{CTT100785043, author = {T. Harakawa and H. Tsunoda and A. Ohkubo and K. Seio and M. Sekine}, title = {Development of an efficient method for phosphorodiamidate bond formation by using inorganic salts}, journal = {Bioorganic & Medicinal Chemistry Letters}, year = 2012, } @article{CTT100785039, author = {A. Ohkubo and N. Tago and A. Yokouchi and ; Y. Nishino and K. Yamada and H. Tsunoda and K. Seio and M. Sekine}, title = {Synthesis of 5 '-terminal capped oligonucleotides using O-N phosphoryl migration of phosphoramidite derivatives}, journal = {ORGANIC LETTERS}, year = 2012, } @article{CTT100785041, author = {Y. Masaki and R. Miyasaka and K. Hirai and H. Tsunoda and A. Ohkubo and K. Seio and M. Sekine}, title = {Prediction of the stability of modified RNA duplexes based on deformability analysis: Oligoribonucleotide derivatives modified with 2 '-o-cyanoethyl-5-propynyl-2-thiouridine as a promising component}, journal = {CHEMICAL COMMUNICATIONS}, year = 2012, } @article{CTT100785042, author = {T. Kanamori and Y. Masaki and M. Mizuta and H. Tsunoda and A. Ohkubo and M. Sekine and K. Seio}, title = {DNA duplexes and triplex-forming oligodeoxynucleotides incorporating modified nucleosides forming stable and selective triplexes}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, year = 2012, } @article{CTT100785038, author = {K. Seio and S. Kurohagi and E. Kodama and Y. Masaki and H. Tsunoda and A. Ohkubo and M. Sekine}, title = {Short-RNA selective binding of oligonucleotides modified using adenosine and guanosine derivatives that possess cyclohexyl phosphates as substituents}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, year = 2012, } @article{CTT100785040, author = {A. Ohkubo and Y. Nishino and Y. Ito and H. Tsunoda and K. Seio and M. Sekine}, title = {Formation of new base pairs between inosine and 5-methyl-2-thiocytidine derivatives}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, year = 2012, } @article{CTT100785047, author = {A. Ohkubo and A. Yokouchi and K. Yamada and H. Tsunoda and K. Seio and M. Sekine}, title = {Synthesis and properties of oligonucleotides having 5 '-terminal 2,2,7-trimethylguanosine cap analogues}, journal = {NUCLEIC ACID THERAPEUTICS}, year = 2011, } @article{CTT100785044, author = {T. Yamada and N. Okaniwa and H. Saneyoshi and A. Ohkubo and K. Seio and T. Nagata and Y. Aoki and S. Takeda and M. Sekine}, title = {Synthesis of 2 '-O- 2-(N-methylcarbamoyl)ethyl ribonucleosides using oxa-michael reaction and chemical and biological properties of oligonucleotide derivatives incorporating these modified ribonucleosides}, journal = {JOURNAL OF ORGANIC CHEMISTRY}, year = 2011, } @article{CTT100785045, author = {H. Tsunoda and T. Kudo and Y. Masaki and A. Ohkubo and K. Seio and M. Sekine}, title = {Biochemical behavior of N-oxidized cytosine and adenine bases in DNA polymerase-mediated primer extension reactions}, journal = {NUCLEIC ACIDS RESEARCH}, year = 2011, } @article{CTT100785049, author = {S. Q. Cao and I. Okamoto and H. Tsunoda and A. Ohkubo and K. Seio and M. Sekine}, title = {Synthesis and triplex-forming properties of oligonucleotides containing thio-substituted C-nucleoside 4-thiopseudoisocytidine}, journal = {TETRAHEDRON LETTERS}, year = 2011, } @article{CTT100785046, author = {M. Sekine and Y. Oeda and Y. Iijima and H. Taguchi and A. Ohkubo and K. Seio}, title = {Synthesis and hybridization properties of 2 '-O-methylated oligoribonucleotides incorporating 2 '-O-naphthyluridines}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, year = 2011, } @article{CTT100785048, author = {A. Ohkubo and Y. Nishino and A. Yokouchi and Y. Ito and Y. Noma and Y. Kakishima and Y. Masaki and H. Tsunoda and K. Seio and M. Sekine}, title = {Stable triplex formation using the strong stacking effect of consecutive thionucleoside moieties}, journal = {CHEMICAL COMMUNICATIONS}, year = 2011, } @article{CTT100785053, author = {H. Tsunoda and T. Kudo and A. Ohkubo and K. Seio and M. Sekine}, title = {Synthesis of oligodeoxynucleotides using fully protected deoxynucleoside 3 '-phosphoramidite building blocks and base recognition of oligodeoxynucleotides incorporating N-3-cyano-ethylthymine}, journal = {MOLECULES}, year = 2010, } @article{CTT100785050, author = {K. Yamada and H. Taguchi and A. Ohkubo and K. Seio and M. Sekine}, title = {Synthesis and biochemical properties of oligodeoxynucleotides acylated by the chemically stable 2-(trimethylsilyl)benzoyl (TMSBz) group at the 5 ' or 3 ' terminus}, journal = {Tetrahedron letters}, year = 2010, } @article{CTT100785058, author = {A. Ohkubo and T. Sakaue and H. Tsunoda and K. Seio and M. Sekine}, title = {Synthesis and hybridization properties of oligonucleotides incorporating bi- and tricyclic cytosine derivatives}, journal = {Chemistry letters}, year = 2010, } @article{CTT100785060, author = {A. Ohkubo and Y. Kuwayama and Y. Nishino and H. Tsunoda and K. Seio and M. Sekine}, title = {Oligonucleotide synthesis involving deprotection of amidine-type protecting groups for nucleobases under acidic conditions}, journal = {ORGANIC LETTERS}, year = 2010, } @article{CTT100785062, author = {Y. Masaki and R. Miyasaka and A. Ohkubo and K. Seio and M. Sekine}, title = {Linear relationship between deformability and thermal stability of 2 '-O-modified RNA hetero duplexes}, journal = {JOURNAL OF PHYSICAL CHEMISTRY B}, year = 2010, } @article{CTT100785061, author = {Y. Masaki and A. Ohkubo and K. Seio and M. Sekine}, title = {Synthesis of 6-N-(benzothiazol-2-yl)deoxyadenosine and its exciton-coupled circular dichroism}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY}, year = 2010, } @article{CTT100785055, author = {K. Seio and M. Shiraishi and E. Utagawa and A. Ohkubo and M. Sekine}, title = {Synthesis of oligodeoxynucleotides using the oxidatively cleavable 4-methoxytritylthio (MMTrS) group for protection of the 5 '-hydroxyl group}, journal = {NEW JOURNAL OF CHEMISTRY}, year = 2010, } @article{CTT100785515, author = {Y. Oeda and Y. Iijima and H. Taguchi and A. Ohkubo and K. Seio and M. Sekine}, title = {Microwave-Assisted Synthesis of 2 '-O-Aryluridine Derivatives}, journal = {ORGANIC LETTERS}, year = 2009, } @article{CTT100785506, author = {K. Seio and R. Tawarada and T. Sasami and M. Serizawa and M. Ise and A. Ohkubo and M. Sekine}, title = {Synthesis and hybridization of 2 '-O-methyl-RNAs incorporating 2 '-O-carbamoyluridine and unique participation of the carbamoyl group in U-G base pair}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY}, year = 2009, } @article{CTT100785549, author = {Seio Kohji and Miyazaki Kazuya and Kurohagi Sayako and Masaki Yoshiaki and Tsunoda Hirosuke and Ohkubo Akihiro and Sekine Mitsuo}, title = {Synthesis and properties of terminally modified oligonucleotides capable of short-RNA selective hybridization.}, journal = {Nucleic acids symposium series (2004)}, year = 2009, } @article{CTT100785504, author = {K. Yamada and H. Taguchi and A. Ohkubo and K. Seio and M. Sekine}, title = {Synthesis and properties of nucleoside derivatives acylated by chemically stable 2-(trimethylsilyl)benzoyl group}, journal = {Bioorganic & Medicinal Chemistry}, year = 2009, } @article{CTT100785512, author = {A. Ohkubo and K. Sasaki and Y. Noma and H. Tsunoda and K. Seio and M. Sekine}, title = {Efficient solid-phase synthesis of oligodeoxynucleotides having a 5 '-terminal 2,2,7-trimethylguanosine pyrophosphate linkage}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY}, year = 2009, } @article{CTT100785516, author = {M. Mizuta and K. Seio and A. Ohkubo and M. Sekine}, title = {Fluorescence Properties of Pyrimidopyrimidoindole Nucleoside dC(PPI) Incorporated into Oligodeoxynucleotides}, journal = {JOURNAL OF PHYSICAL CHEMISTRY B}, year = 2009, } @article{CTT100785513, author = {A. Ohkubo and Y. Noma and K. Aoki and H. Tsunoda and K. Seio and M. Sekine}, title = {Introduction of 3 '-Terminal Nucleosides Having a Silyl-Type Linker into Polymer Supports without Base Protection}, journal = {JOURNAL OF ORGANIC CHEMISTRY}, year = 2009, } @article{CTT100785509, author = {T. Sasami and R. Tawarada and A. Ohkubo and M. Sekine and K. Seio}, title = {Computational evaluation of the stability of 2 '-O-methyl-RNA/RNA duplexes incorporating 3-deazaguanine derivatives by ab initio calculations and a molecular dynamics simulation}, journal = {JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM}, year = 2009, } @article{CTT100785510, author = {T. Sasami and Y. Odawara and A. Ohkubo and M. Sekine and K. Seio}, title = {Synthesis of oligodeoxynucleotides incorporating 2-N-carbamoylguanine and evaluation of the hybridization properties}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY}, year = 2009, } @article{CTT100785511, author = {I. Okamoto and S. Q. Cao and H. Tanaka and K. Seio and M. Sekine}, title = {Synthesis of 4-Thiopseudoisocytidine and 4-Thiopseudouridine as Components of Triplex-forming Oligonucleotides}, journal = {CHEMISTRY LETTERS}, year = 2009, } @article{CTT100785517, author = {K. Miyata and R. Tamamushi and H. Tsunoda and A. Ohkubo and K. Seio and M. Sekine}, title = {Synthesis and Triplex Formation of Oligonucleotides Containing 8-Thioxodeoxyadenosine}, journal = {Organic Letters}, year = 2009, } @article{CTT100785507, author = {K. Seio and Y. Takaku and K. Miyazaki and S. Kurohagi and Y. Masaki and A. Ohkubo and M. Sekine}, title = {Synthesis of terminally modified oligonucleotides and their hybridization dependence on the size of the target RNAs}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, year = 2009, } @article{CTT100785514, author = {A. Ohkubo and R. Kasuya and K. Miyata and H. Tsunoda and K. Seio and M. Sekine}, title = {New thermolytic carbamoyl groups for the protection of nucleobases}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, year = 2009, } @article{CTT100785505, author = {R. Tawarada and K. Seio and M. Sekine}, title = {Mechanistic studies on oxidative condensation of a thymidine 3 '-H-phosphonate derivative with 3 '-O-acetylthymidine}, journal = {Arkivoc}, year = 2009, } @article{CTT100785524, author = {K. Seio and M. Mizuta and K. Tasaki and K. Tamaki and A. Ohkubo and M. Sekine}, title = {Hybridization-dependent fluorescence of oligodeoxynucleotides incorporating new pyrene-modified adenosine residues}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY}, year = 2008, } @article{CTT100785553, author = {M. Mizuta and J. I. Banba and T. Kanamori and R. Tawarada and A. Ohkubo and M. Sekine and K. Seio}, title = {New nucleotide pairs for stable DNA triplexes stabilized by stacking interaction}, journal = {JOURNAL OF THE AMERICAN CHEMICAL SOCIETY}, year = 2008, } @article{CTT100785527, author = {A. Ohkubo and Y. Kuwayama and T. Kudo and H. Tsunoda and K. Seio and M. Sekine}, title = {O-selective condensation using P-N bond cleavage in RNA synthesis without base protection}, journal = {Organic letters}, year = 2008, } @article{CTT100785526, author = {I. Okamoto and K. Seio and M. Sekine}, title = {Study of the base discrimination ability of DNA and 2 '-O-methylated RNA oligomers containing 2-thiouracil bases towards complementary RNA or DNA strands and their application to single base mismatch detection}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY}, year = 2008, } @article{CTT100785552, author = {A. Ohkubo and R. Kasuya and K. Aoki and A. Kobori and H. Taguchi and K. Seio and M. Sekine}, title = {Efficient synthesis of functionalized oligodeoxyribonucleotides with base-labile groups using a new silyl linker}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY}, year = 2008, } @article{CTT100785525, author = {H. Saneyoshi and K. Tamaki and A. Ohkubo and K. Seio and M. Sekine}, title = {Synthesis and hybridization properties of 2 '-O-(tetrazol-5-yl)ethyl-modified oligonucleotides}, journal = {TETRAHEDRON}, year = 2008, } @article{CTT100785522, author = {K. Taira and S. Nakamura and K. Nakano and D. Maehara and K. Okamoto and S. Arimoto and D. Loakes and L. Worth and R. M. Schaaper and K. Seio and M. Sekine and K. Negishi and T. Negishi}, title = {Binding of MutS protein to oligonucleotides containing a methylated or an ethylated guanine residue, and correlation with mutation frequency}, journal = {MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS}, year = 2008, } @article{CTT100785528, author = {A. Ohkubo and R. Kasuya and K. Sakamoto and K. Miyata and H. Taguchi and H. Nagasawa and T. Tsukahara and T. Watanobe and Y. Maki and K. Seio and M. Sekine}, title = {'Protected DNA Probes' capable of strong hybridization without removal of base protecting groups}, journal = {NUCLEIC ACIDS RESEARCH}, year = 2008, } @article{CTT100785518, author = {H. Tsunoda and A. Ohkubo and H. Taguchi and K. Seio and M. Sekine}, title = {Synthesis and properties of DNA oligomers containing 2 '-deoxynucleoside N-oxide derivatives}, journal = {JOURNAL OF ORGANIC CHEMISTRY}, year = 2008, } @article{CTT100785523, author = {M. Sumino and A. Ohkubo and H. Taguchi and K. Seio and M. Sekine}, title = {Synthesis and properties of oligodeoxynucleotides containing 5-carboxy-2'-deoxycytidines}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, year = 2008, } @article{CTT100785519, author = {R. Tawarada and K. Seio and M. Sekine}, title = {Synthesis and properties of oligonucleotides with iodo-substituted aromatic aglycons: Investigation of possible halogen bonding base pairs}, journal = {JOURNAL OF ORGANIC CHEMISTRY}, year = 2008, } @article{CTT100785559, author = {A. Ohkubo and K. Tanaka and H. Taguchi and K. Seio and H. Nagasawa and T. Tsukahara and M. Sekine}, title = {An effective method for the in situ synthesis of DNA-CPG conjugates using chemical ligation technology as tools for SNP analysis}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, year = 2007, } @article{CTT100785544, author = {Saneyoshi Hisao and Okamoto Itaru and Masaki Yoshiaki and Ohkubo Akihiro and Seio Kohji and Mitsuo}, title = {Facile synthesis of 2 '-O-cyanoethyluridine by ring-opening reaction of 2,2 '-anhydrouridine with cyanoethyl trimethylsilyl ether in the presence of BF3 center dot Et2O}, journal = {Tetrahedron Letters}, year = 2007, } @article{CTT100785558, author = {H. Saneyoshi and K. Ando and K. Seio and M. Sekine}, title = {Chemical synthesis of RNA via 2 '-O-cyanoethylated intermediates}, journal = {TETRAHEDRON}, year = 2007, } @article{CTT100785554, author = {E. Utagawa and A. Ohkubo and M. Sekine and K. Seio}, title = {Synthesis of branched Oligonucleotides with three different sequences using an oxidatively removable tritylthio group}, journal = {JOURNAL OF ORGANIC CHEMISTRY}, year = 2007, } @article{CTT100785557, author = {T. Sasami and Y. Odawara and A. Ohkubo and M. Sekine and K. Seio}, title = {Synthesis and hybridization properties of oligodeoxynucleotides incorporating 2-N-carbamoylguanine derivatives as guanine analogs}, journal = {TETRAHEDRON LETTERS}, year = 2007, } @article{CTT100785560, author = {A. Ohkubo and H. Taguchi and K. Seio and H. Nagasawa and T. Tsukahara and M. Sekine}, title = {A new hydrophobic linker effective for the in situ synthesis of DNA-CPG conjugates as tools for SNP analysis}, journal = {TETRAHEDRON LETTERS}, year = 2007, } @article{CTT100785561, author = {M. Mizuta and K. Seio and K. Miyata and M. Sekine}, title = {Fluorescent pyrimidopyrimidoindole nucleosides: Control of photophysical characterizations by substituent effects}, journal = {JOURNAL OF ORGANIC CHEMISTRY}, year = 2007, } @article{CTT100785566, author = {B. Karwowski and K. Seio and M. Sekine}, title = {Chemical properties of 4,5-di(ethoxycarbonyl)-1,3-dioxolan-2-yl (DECDO) as a hydroxyl protecting group of the 2 '-hydroxyl function in ribonucleosides}, journal = {JOURNAL OF HETEROCYCLIC CHEMISTRY}, year = 2007, } @article{CTT100785556, author = {K. Seio and T. Sasami and A. Ohkubo and K. Ando and M. Sekine}, title = {Highly selective recognition of cytosine over uracil and adenine by a guanine analogue, 2-N-Acetyl-3-deazaguanine, in 2 '-O-Methyl-RNA/RNA and DNA duplexes}, journal = {JOURNAL OF THE AMERICAN CHEMICAL SOCIETY}, year = 2007, } @article{CTT100785565, author = {K. Miyata and R. Mineo and R. Tamamushi and M. Mizuta and A. Ohkubo and H. Taguchi and K. Seio and T. Santa and M. Sekine}, title = {Synthesis and fluorescent properties of bi- and tricyclic 4-N-carbamoyldeoxycytidine derivatives}, journal = {JOURNAL OF ORGANIC CHEMISTRY}, year = 2007, } @article{CTT100785555, author = {K. Seio and T. Terada and M. Mizuta and A. Ohkubo and H. Taguchi and M. Sekine}, title = {Synthesis and hybridization properties of oligodeoxynucleotides with long-chain linkers}, journal = {HELVETICA CHIMICA ACTA}, year = 2007, } @article{CTT100785563, author = {M. Mizuta and K. Seio and K. Miyata and A. Ohkubo and H. Taguchi and M. Sekine}, title = {A pyrimidopyrimidoindole nucleoside (dC(PPI)): Photophysical properties and thermal stability of the modified DNA duplexes}, journal = {NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS}, year = 2007, } @article{CTT100785567, author = {E. Utagawa and M. Sekine and K. Seio}, title = {cis-tetrahydrofuran-3,4-diol structure as a key skeleton of new protecting groups removable by self-cyclization under oxidative conditions}, journal = {JOURNAL OF ORGANIC CHEMISTRY}, year = 2006, } @article{CTT100785572, author = {K. Miyata and R. Tamamushi and A. Ohkubo and H. Taguchi and K. Seio and T. Santa and M. Sekine}, title = {Synthesis and properties of a new fluorescent bicyclic 4-N-carbamoyldeoxycytidine derivative}, journal = {ORGANIC LETTERS}, year = 2006, } @article{CTT100785570, author = {I. Okamoto and K. Shohda and K. Seio and M. Sekine}, title = {Incorporation of 2 '-O-methyl-2-thiouridine into oligoribonucleotides induced stable A-form structure}, journal = {CHEMISTRY LETTERS}, year = 2006, } @article{CTT100785601, author = {H. Taguchi and A. Ohkubo and M. Sekine and K. Seio and H. Kakeya and H. Osada and T. Sasaki}, title = {Synthesis and biological properties of new phosmidosine analogs having an N-acylsulfamate linkage}, journal = {NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS}, year = 2006, } @article{CTT100785582, author = {K. Seio and T. Miyashita and K. Sato and M. Sekine}, title = {Synthesis and properties of new nucleotide analogues possessing squaramide moieties as new phosphate isosters}, journal = {EUROPEAN JOURNAL OF ORGANIC CHEMISTRY}, year = 2005, } @article{CTT100785578, author = {M. Sekine and M. Aoyagi and M. Ushioda and A. Ohkubo and K. Seio}, title = {Chemically stabilized phenylboranylidene groups having a dimethoxytrityl group as a colorimetrically detectable protecting group designed for cis-1,2-diol functions of ribonucleosides in the solid-phase synthesis of m(2)(2,2)G5 ' ppT}, journal = {JOURNAL OF ORGANIC CHEMISTRY}, year = 2005, } @article{CTT100785579, author = {K. Seio and H. Ukawa and K. Shohda and M. Sekine}, title = {Computational evaluation of intermolecular interactions of a universal base 3-nitropyrrole in stacked dimers and DNA duplexes}, journal = {JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS}, year = 2005, } @article{CTT100785581, author = {K. Seio and T. Negishi and K. Negishi and M. Sekine}, title = {Mild and facile deprotection for the synthesis of oligodeoxynucleotide incorporating a 6-O-ethyl-deoxyguanosine}, journal = {LETTERS IN ORGANIC CHEMISTRY}, year = 2005, } @article{CTT100785585, author = {K. Seio and T. Sasaki and K. Yanagida and M. Baba and M. Sekine}, title = {Synthesis of benzodithiol-2-yl-substituted nucleoside derivatives as lead compounds having anti-bovine viral diarrhea virus activity}, journal = {JOURNAL OF MEDICINAL CHEMISTRY}, year = 2004, } @article{CTT100785586, author = {A. Ohkubo and Y. Ezawa and K. Seio and M. Sekine}, title = {O-selectivity and utility of phosphorylation mediated by phosphite triester intermediates in the N-unprotected phosphoramidite method}, journal = {JOURNAL OF THE AMERICAN CHEMICAL SOCIETY}, year = 2004, } @article{CTT100785584, author = {K. Seio and E. Utagawa and M. Sekine}, title = {New protected protecting groups for the 5 '-hydroxy group of deoxynucleosides by use of 2-(hydroxymethyl)- and 2-[(methylamino)methyl]benzoyl skeletons and oxidatively cleavable tritylthio and (4-methoxytrityl)thio groups}, journal = {HELVETICA CHIMICA ACTA}, year = 2004, } @article{CTT100785595, author = {A. Kobori and K. Miyata and M. Ushioda and K. Seio and M. Sekine}, title = {A new silyl ether-type linker useful for the automated synthesis of oligonucleotides having base-labile protective groups}, journal = {CHEMISTRY LETTERS}, year = 2002, } @inproceedings{CTT100785103, author = {印出健志 and 正木慶昭 and 宮武佑弥 and 関根光雄 and 清尾康志}, title = {α-デオキシヌクレオシドを含むオリゴヌクレオチドのアンチパラレル型三重鎖形成能と塩基識別能}, booktitle = {}, year = 2018, } @inproceedings{CTT100785100, author = {T. Inde and Y. Masaki and A. Maruyama and Y. Ito and N. Makio and Y. Miyatake and T. Tomori and M. Sekine and K. Seio}, title = {Synthesis of oligodeoxyribonucleotides containing 2-N-heteroarylguanine residues and their effect on higher-order structure stability}, booktitle = {}, year = 2017, } @inproceedings{CTT100785099, author = {印出健志 and 丸山敦也 and 伊藤 優 and 牧尾直明 and 友利貴人 and 正木慶昭 and 関根光雄 and 清尾康志}, title = {2 位のアミノ基にヘテロアリール環を導入したデオキシグアノシン誘導体の合成と オリゴヌクレオチド中での性質評価}, booktitle = {}, year = 2017, } @inproceedings{CTT100785092, author = {Yoshiaki Masaki and Mitsuo Sekine and KOHJI SEIO}, title = {Relationship between deformability of sugar-modified RNA duplexes and their melting temperatures}, booktitle = {}, year = 2017, } @inproceedings{CTT100785089, author = {清尾康志 and 正木慶昭 and 山本恵士 and 印出健志 and 入山友輔 and 中島宏之 and 金木達朗 and 黒田雄介 and 古川賢 and 谷端 淳 and 永田哲也 and 武田伸一 and 関根 光雄}, title = {2’-水酸基にカルバモイルエチル型修飾を有する人工核酸を用いたアンチセンス核酸の開発}, booktitle = {}, year = 2017, } @inproceedings{CTT100785091, author = {正木 慶昭 and 宮坂 隆太 and 山本 恵士 and 吉田 圭汰 and 関根 光雄 and 清尾 康志}, title = {糖部修飾オリゴヌクレオチドの変形能解析と二重鎖融解温度の関係}, booktitle = {}, year = 2017, } @inproceedings{CTT100723580, author = {Takeshi Inde and Yoshiaki Masaki and Mitsuo Sekine and Kohji Seio}, title = {Base Pair Recognition of Alpha-deoxyribonucleosides with Unmodified Nucleobase and 8-Oxo-adenine in Antiparallel DNA Triplex}, booktitle = {}, year = 2016, } @inproceedings{CTT100722469, author = {正木 慶昭 and 吉田 圭汰 and 山本 恵士 and 関根 光雄 and 清尾 康志}, title = {糖部化学修飾RNA二重鎖の変形能と二重鎖融解温度の関係}, booktitle = {}, year = 2016, } @inproceedings{CTT100723585, author = {Takahito Tomori and Kento Nagaoka and Yuya Miyatake and Yoshiaki Masaki and Mitsuo Sekine and Kohji seio}, title = {Synthesis and Enzymatic Properties of C-nucleoside Triphosphate Containing Pyridazin-3-one As a Uracil Analog}, booktitle = {}, year = 2016, } @inproceedings{CTT100723600, author = {Leo Takeshita and Kentaro Ohno and Yoshiaki Masaki and Mitsuo Sekine and Kohji Seio}, title = {Chemical and Enzymatic Synthesis of Photo-caged DNA containing N1-Nitrobenzyl-2´-deoxypseudouridine for UV Dependent Regulation of Transcription}, booktitle = {}, year = 2016, } @inproceedings{CTT100722445, author = {Yoshiaki Masaki and Ryuta Miyasaka and Keishi Yamamoto and Keita Yoshida and Akihiro Ohkubo and Mitsuo Sekine and Kohji Seio}, title = {Deformability analysis of chemically modified RNA and its applicability for estimation of RNA duplex stability}, booktitle = {}, year = 2016, } @inproceedings{CTT100724410, author = {宮村 大地 and 金森 功吏 and 正木 慶昭 and 関根 光雄 and 清尾 康志}, title = {塩基部5位に3-メチルベンゾフラン誘導体を導入した2'-デオキシウリジンの合成と蛍光特性}, booktitle = {}, year = 2016, } @inproceedings{CTT100724887, author = {Hiroya Asami and Munefumi Tokugawa and Yoshiaki Masaki and Eric Gloaguen and Kohji Seio and Mitsuo Sekine and Michel Mons}, title = {An Effective Molecular Model for Nanosecond Laser Spectroscopy of Short-lived Nucleobase: Application to Anharmonic Vibrational Analysis in the Mid-IR Region}, booktitle = {}, year = 2016, } @inproceedings{CTT100724885, author = {小田雄貴 and 伊藤比佑吾 and 金森功吏 and 大窪章寛 and 正木慶昭 and 関根光雄 and 清尾康志}, title = {塩基性条件下不安定なヌクレオシド三リン酸の新規合成法の開発}, booktitle = {}, year = 2016, } @inproceedings{CTT100724884, author = {岸村智太 and 印出健志 and 正木慶昭 and 関根光雄 and 清尾康志}, title = {アンチセンス核酸の5´末端に糖を修飾するためのリンカーの設計と合成}, booktitle = {}, year = 2016, } @inproceedings{CTT100724389, author = {北川 諒 and 田胡 信広 and 関谷 彰太 and 正木 慶昭 and 関根 光雄 and 清尾 康志}, title = {スルホンアミド骨格を有するヌクレオシド誘導体の合成と性質}, booktitle = {}, year = 2016, } @inproceedings{CTT100724394, author = {山本 恵士 and 正木 慶昭 and 吉田圭汰 and 入山 友輔 and 中嶋 宏之 and 金木 達朗 and 関根 光雄 and 清尾 康志}, title = {2-(N-エチルカルバモイル)エチル構造を有する糖部修飾核酸の合成と性質}, booktitle = {}, year = 2016, } @inproceedings{CTT100724396, author = {友利 貴人 and 長岡 健斗 and 宮武 佑弥 and 正木 慶昭 and 関根 光雄 and 清尾 康志}, title = {ピリダジン-3-オンを核酸塩基部に有する/C/ヌクレオシドの合成と性質}, booktitle = {}, year = 2016, } @inproceedings{CTT100724400, author = {竹下 玲央 and 大野 健太郎 and 正木 慶昭 and 関根 光雄 and 清尾 康志}, title = {DNA-タンパク質相互作用の光制御をめざした光ケージされたデオキシシュードウリジンを含む核酸の合成および性質}, booktitle = {}, year = 2016, } @inproceedings{CTT100724896, author = {Yoshiaki Masaki and Keishi Yamamoto and Takeshi Inde and Tetsuya Nagata and Jun Tanihata and Yusuke Iriyama and Shinishi Takeda and Mitsuo Sekine and KOHJI SEIO}, title = {Enhancement of exon skipping efficiency by using antisense oligonucleotides containing 2-thiothymidine derivatives}, booktitle = {}, year = 2015, } @inproceedings{CTT100723567, author = {Yoshiaki Masaki and Keishi Yamamoto and Takeshi Inde and Tetsuya Nagata and Jun Tanihata and Yusuke Iriyama and Shin'ichi Takeda and Kohji Seio and Mitsuo Sekine}, title = {Enhancement of exon skipping by 2´-O-(N-methylcarbamoyl)ethyl (MCE) and/or nucleobase modified nucleosides incorporation into phosphorothioate oligonucleotides}, booktitle = {}, year = 2015, } @inproceedings{CTT100723963, author = {Kentaro Ohno and Leo Takeshita and Yoshihiro Iijima and Takashi Kanamori and Yoshiaki Masaki and Mitsuo Sekine and Kohji Seio}, title = {Synthesis of oligonucleotides containing photo-caged 2´ -deoxypseudouridine for the regulation of DNA-protein interaction}, booktitle = {}, year = 2015, } @inproceedings{CTT100723961, author = {Ayano Yamazaki and Kei Yamaguchi and Takashi Kanamori and Yoshiaki Masaki and Mitsuo Sekine and Kohji Seio}, title = {Synthesis of oligodeoxynucleotides containing 2´-deoxy-pseudoisocytidine for the development of chemically modified DNA duplexes and triplexes}, booktitle = {}, year = 2015, } @inproceedings{CTT100723956, author = {Yu Ito and Takashi Kanamori and Yoshiaki Masaki and Akihiro Ohkubo and Kohji Seio and Mitsuo Sekine}, title = {Synthesis of deoxyuridine derivatives modified with 2,4-diaminopyrimidine moiety for the development of high affinity triplex forming oligonucleotides}, booktitle = {}, year = 2015, } @inproceedings{CTT100724882, author = {田胡信広 and 北川諒 and Adam Kotolik and Nathaniel E. Clark and Eric J. Montemayor and P. John Hart and 正木 慶昭 and 金森 功吏 and 関根 光雄 and 清尾 康志 and Masad J. Damha}, title = {5'-アミノグアノシンを分岐部位に導入した2'-5'修飾分岐RNAの合成と性質}, booktitle = {}, year = 2015, } @inproceedings{CTT100724858, author = {山本 恵士 and 正木 慶昭 and 石井 陽大 and 印出 健志 and 金森 功吏 and 関根 光雄 and 清尾 康志}, title = {2'-O-メチルカルバモイルエチル修飾2-チオリボチミジンを含むオリゴヌクレオチドの合成と性質}, booktitle = {}, year = 2015, } @inproceedings{CTT100724868, author = {大野 健太郎 and 正木 慶昭 and 金森 功吏 and 関根 光雄 and 清尾 康志}, title = {光ケージヌクレオシド三リン酸の合成と性質}, booktitle = {}, year = 2015, } @misc{CTT100786540, author = {清尾康志 and 岡本到 and 関根光雄}, title = {2-チオウリジンを利用したアンチセンス核酸の化学合成と性質}, year = 2004, }