論文

• Ksenia Kuznetsova, Noemie M. Chabot, Martino Ugolini, Edlyn Wu, Manan Lalit, Haruka Oda, Yuko Sato, Hiroshi Kimura, Florian Jug, Nadine L. Vastenhouw. Nanog organizes transcription bodies, Current Biology, Vol. 33, No. 1, pp. 164-173.e5, Dec. 2022.  公式リンク  
  
• Yohei Kono, Stephen A. Adam, Yuko Sato, Karen L. Reddy, Yixian Zheng, Ohad Medalia, Robert D. Goldman, Hiroshi Kimura, Takeshi Shimi. Nucleoplasmic lamin C rapidly accumulates at sites of nuclear envelope rupture with BAF and cGAS, J Cell Biol, Vol. 221, No. 12, e202201024, Oct. 2022.
• Yancen Dai, Yuko Sato, Bo Zhu, Tetsuya Kitaguchi, Hiroshi Kimura, Farid J. Ghadess, Hiroshi Ueda. Intra Q-body: an antibody-based fluorogenic probe for intracellular proteins that allows live cell imaging and sorting, Chemical Science, The Royal Society of Chemistry, Vol. 13, Issue 33, p. 9739-9748, Aug. 2022.
• Rang FJ, de Luca KL, de Vries SS, Valdes-Quezada C, Boele E, Nguyen PD, Guerreiro I, Sato Y, Kimura H, Bakkers J, Kind J. Single-cell profiling of transcriptome and histone modifications with EpiDamID, Mol Cell, Mar. 2022.
• Hiroshi Kimura, Yuko Sato. Imaging transcription elongation dynamics by new technologies unveils the organization of initiation and elongation in transcription factories, Current Opinion in Cell Biology, Volume 74, Page 71-79, Feb. 2022.
• Uchino S, Ito Y, Sato Y, Handa T, Ohkawa Y, Tokunaga M, Kimura H. Live imaging of transcription sites using an elongating RNA polymerase II-specific probe., J Cell Biol, Vol. 221, No. 2, p. e202104134 (23 pages), Dec. 2021.  公式リンク  
  
• Yuko Sato, Masaru Nakao, Hiroshi Kimura. Live-cell imaging probes to track chromatin modification dynamics, Microscopy (Oxf), Vol. 70, Issue 5, Page 415-422, Oct. 2021.
• Yuko Sato, Hiroshi Kimura. Multiplexed Imaging of Posttranslational Modifications of Endogenous Proteins in Live Cells, Methods in Molecular Biology, volume 2350, page 31-41, July 2021.
• Yuko Sato, Hiroshi Kimura. Dynamic Behavior of Inactive X Chromosome Territory During the Cell Cycle as Revealed by H3K27me3-Specific Intracellular Antibody, Methods in Molecular Biology, volume 1342, June 2021.
• Mio K. Shibuta, Takuya Sakamoto, Tamako Yamaoka, Mayu Yoshikawa, Shusuke Kasamatsu, Noriyoshi Yagi, Satoru Fujimoto, Takamasa Suzuki, Satoshi Uchino, Yuko Sato, Hiroshi Kimura, Sachihiro Matsunaga. A live imaging system to analyze spatiotemporal dynamics of RNA polymerase II modification in Arabidopsis thaliana, Communications Biology, Volume 4, May 2021.
• Uchino S, Ito Y, Sato Y, Handa T, Yasuyuki Ohkawa, Tokunaga M, Kimura H. Visualizing transcription sites in living cells using a genetically encoded probe specific for the elongating form of RNA polymerase II, bioRxiv, No. 2021.04.27, p. 441582, Apr. 2021.  公式リンク  
  
• Lennart Hilbert, Yuko Sato, Ksenia Kuznetsova, Tommaso Bianucci, Hiroshi Kimura, Frank Jülicher, Alf Honigmann, Vasily Zaburdaev, Nadine L. Vastenhouw. Transcription organizes euchromatin via microphase separation, Nature Communications, volume 12, No. 1, pp. 1360, Mar. 2021.
• Sjoerd J D Tjalsma, Mayako Hori, Yuko Sato, Aurelie Bousard, Akito Ohi, Ana Cláudia Raposo, Julia Roensch, Agnes Le Saux, Jumpei Nogami, Kazumitsu Maehara, Tomoya Kujirai, Tetsuya Handa, Sandra Bagés-Arnal, Yasuyuki Ohkawa, Hitoshi Kurumizaka, Simão Teixeira da Rocha, Jan J Żylicz, Hiroshi Kimura, Edith Heard. H4K20me1 and H3K27me3 are concurrently loaded onto the inactive X chromosome but dispensable for inducing gene silencing, EMBO reports, volume 22, Issue 3, e51989, Mar. 2021.
• Yusuke Fujiwara, Yuki Yamanashi, Akiko Fujimura, Yuko Sato, Tomoya Kujirai, Hitoshi Kurumizaka, Hiroshi Kimura, Kenzo Yamatsugu, Shigehiro A. Kawashima, Motomu Kanai. Live-Cell Epigenome Manipulation by Synthetic Histone Acylation Catalyst System, Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 4, Jan. 2021.
• Chenjiang Liu, Yoshihiro Kobashigawa, Soichiro Yamauchi, Yuya Toyota, Manaka Teramoto, Yuka Ikeguchi, Natsuki Fukuda, Takashi Sato, Yuko Sato, Hiroshi Kimura, Hiroshi Morioka. Preparation of single-chain Fv antibodies in the cytoplasm of Escherichia coli by simplified and systematic chaperone optimization, The Journal of Biochemistry,, Volume 166, Issue 6, Page 455-462, Sept. 2019.
• Yuko Sato, Lennart Hilbert, Haruka Oda, Yinan Wan, John M. Heddleston, Teng-Leong Chew, Vasily Zaburdaev, Philipp Keller, Timothee Lionnet, Nadine Vastenhouw, Hiroshi Kimura. Histone H3K27 acetylation precedes active transcription during zebrafish zygotic genome activation as revealed by live cell analysis, Development, vol. 146, no. 19, Sept. 2019.
• Chan-I Chung, Yuko Sato, Yuki Ohmuro-Matsuyama, Shinichi Machida, Hitoshi Kurumizaka, Hiroshi Kimura, Hiroshi Ueda. Intrabody-based FRET probe to visualize endogenous histone acetylation, Scientific Reports, Springer-Nature, Vol. 9, No. 1, pp. 10188, July 2019.  公式リンク  
  
• Yuko Sato, Timothy J. Stasevich, Hiroshi Kimura. Visualizing the Dynamics of Inactive X Chromosomes in Living Cells Using Antibody-Based Fluorescent Probes, Methods Mol Biol, Humana, New York, NY, Vol. 1861, pp. 91-102, Sept. 2018.
• Lusy Handoko, Bogumil Kaczkowski, Chung-Chau Hon, Marina Lizio, Masatoshi Wakamori, Takayoshi Matsuda, Takuhiro Ito, Prashanti Jeyamohan, Yuko Sato, Kensaku Sakamoto, Shigeyuki Yokoyama, Hiroshi Kimura, Aki Minoda, Takashi Umehara. JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin states, Epigenetics, Volume 13, Issue 4, Page 410-431, Aug. 2018.
• Akihito Harada, Kazumitsu Maehara, Yusuke Ono, Hiroyuki Taguchi, Kiyoshi Yoshioka, Yasuo Kitajima, Yan Xie, Yuko Sato, Takeshi Iwasaki, Jumpei Nogami, Seiji Okada, Tetsuro Komatsu, Yuichiro Semba, Tatsuya Takemoto, Hiroshi Kimura, Hitoshi Kurumizaka, Yasuyuki Ohkawa. Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration, Nature Communications, vol. 9, Apr. 2018.
• R. Arai, T. Sugawara, Y. Minakuchi, Yuko Sato, A. Toyoda, K. Nabeshima, H. Kimura, A. Kimura. Reduction in chromosome mobility accompanies nuclear organization during early embryogenesis in Caenorhabditis elegans, Scientific reports, Vol. 7, No. 1, pp. 3631, June 2017.
• Yuko Sato, Hiroshi Kimura. Semi-quantitative Analysis of H4K20me1 Levels in Living Cells Using Mintbody, bio-protocol, vol. 7, no. 10, May 2017.
• Yuki Kuniyoshi, Kazumitsu Maehara, Takeshi Iwasaki, Masayasu Hayashi, Yuichiro Semba, Masatoshi Fujita, Yuko Sato, Hiroshi Kimura, Akihito Harada, Yasuyuki Ohkawa. Identification of immunoglobulin gene sequences from a small read number of mRNA-seq using hybridomas, PLOS ONE, vol. 11, no. 10, Oct. 2016.
• Yuko Sato, M. Mukai, H. Kimura. Histone Acetylation on Drosophila Polytene Chromosomes Visualized by Mintbody, Cytologia, vol. 80, no. 4, pp. 383-384, Dec. 2015.  公式リンク  
  
• Kazumitsu Maehara, Akihito Harada, Yuko Sato, Masaki Matsumoto, Keiichi I. Nakayama, Hiroshi Kimura, Yasuyuki Ohkawa. Tissue-specific expression of histone H3 variants diversified after species separation, Epigenetics & Chromatin, vol. 8, Sept. 2015.
• Akihito Harada, Kazumitsu Maehara, Yuko Sato, Daijiro Konno, Taro Tachibana, Hiroshi Kimura, Yasuyuki Ohkawa. Incorporation of histone H3.1 suppresses the lineage potential of skeletal muscle, Nucleic Acids Research, vol. 43, no. 2, pp. 775-786, Jan. 2015.
• Timothy J. Stasevich, Yoko Hayashi-Takanaka, Yuko Sato, Kazumitsu Maehara, Yasuyuki Ohkawa, Kumiko Sakata-Sogawa, Makio Tokunaga, Takahiro Nagase, Naohito Nozaki, James G. McNally, Hiroshi Kimura. Regulation of RNA polymerase II activation by histone acetylation in single living cells, Nature, vol. 516, No. 7530, pp. 272-275, Dec. 2014.
• Timothy J Stasevich, Yuko Sato, Naohito Nozaki, Hiroshi Kimura. Quantifying histone and RNA polymerase II post-translational modification dynamics in mother and daughter cells, Methods, vol. 70, no. 2-3, pp. 77-78, Dec. 2014.
• Jun Ueda, Kazumitsu Maehara, Daisuke Mashiko, Takako Ichinose, Tatsuma Yao, Mayuko Hori, Yuko Sato, Hiroshi Kimura, Yasuyuki Ohkawa, Kazuo Yamagata. Heterochromatin Dynamics during the Differentiation Process Revealed by the DNA Methylation Reporter Mouse, MethylRO, Stem Cell Reports, vol. 2, no. 6, pp. 910-924, June 2014.
• Yasuhiro Arimura, Hiroshi Kimura, Takashi Oda, Koichi Sato, Akihisa Osakabe, Hiroaki Tachiwana, Yuko Sato, Yasuha Kinugasa, Tsuyoshi Ikura, Masaaki Sugiyama, Mamoru Sato, Hitoshi Kurumizaka. Structural basis of a nucleosome containing histone H2A.B/H2A.Bbd that transiently associates with reorganized chromatin, Scientific Reports, vol. 3, Dec. 2013.
• Yuko Sato, Masanori Mukai, Jun Ueda, Michiko Muraki, Timothy J. Stasevich, Naoki Horikoshi, Tomoya Kujirai, Hiroaki Kita, Taisuke Kimura, Seiji Hira, Yasushi Okada, Yoko Hayashi-Takanaka, Chikashi Obuse, Hitoshi Kurumizaka, Atsuo Kawahara, Kazuo Yamagata, Naohito Nozaki, Hiroshi Kimura. Genetically encoded system to track histone modification in vivo, Scientific Reports, vol. 3, Aug. 2013.
• Taichi NISHIZUKA, Yoshiko FUJITA, Yuko SATO, Atushi NAKANO, Akemi KAKINO, Shunji OHSHIMA, Tomomasa KANDA, Ryo YOSHIMOTO, Tatsuya SAWAMURA. Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox, Proc Jpn Acad Ser B Phys Biol Sci, vol. 87, no. 3, pp. 104-113, Mar. 2011.
• Atushi Nakano, Nobutaka Inoue, Yuko Sato, Norihisa Nishimichi, Kenji Takikawa, Yoshiko Fujita, Akemi Kakino, Kazunori Otsui, Saburo Yamaguchi, Haruo Matsuda, Tatsuya Sawamura. LOX-1 mediates vascular lipid retention under hypertensive state, Journal of Hypertension, vol. 28, no. 6, pp. 1273-1280, June 2010.
• Tetsuya Matsumoto, Masatoshi Fujita, Tatsuya Sawamura, Akemi Kakino, Yuko Sato, Yoshiko Fujita, Haruo Matsuda, Mamoru Nakanishi, Kagehiro Uchida, Izuru Nakae, Hiroshi Kanda, Akira Yoshida, Kunihisa Miwa, Hideki Hayashi, Kenichi Mitsunami, Minoru Horie. Pitavastatin reduces lectin-like oxidized low-density lipoprotein receptor-1 ligands in hypercholesterolemic humans, Lipids, vol. 45, no. 4, pp. 329-335, Apr. 2010.
• Tomohide Takaya, Hiromichi Wada, Tatsuya Morimoto, Yoichi Sunagawa, Teruhisa Kawamura, Rieko Takanabe-Mori, Akira Shimatsu, Yoshiko Fujita, Yuko Sato, Masatoshi Fujita, Takeshi Kimura, Tatsuya Sawamura, Koji Hasegawa. Left ventricular expression of lectin-like oxidized low-density lipoprotein receptor-1 in failing rat hearts, Circulation Journal, vol. 74, no. 4, pp. 723-729, Apr. 2010.
• Yoshiko Fujita, Akemi Kakino, Mariko Harada-Shiba, Yuko Sato, Kazunori Otsui, Ryo Yoshimoto, Tatsuya Sawamura. C-reactive protein uptake by macrophage cell line via class-A scavenger receptor, Clinical Chemistry, vol. 56, no. 3, pp. 478-481, Mar. 2010.
• Shin Iwamoto, Norihisa Nishimichi, Yoshiko Tateishi, Yuko Sato, Hiroyuki Horiuchi, Shuichi Furusawa, Tatsuya Sawamura, Haruo Matsuda. Generation and characterization of chicken monoclonal antibodies against human LOX-1, MAbs, vol. 1, no. 4, pp. 357-363, July 2009.
• Nobutaka Inoue, Tomonori Okamura, Yoshihiro Kokubo, Yoshiko Fujita, Yuko Sato, Mamoru Nakanishi, Kazuki Yanagida, Akemi Kakino, Shin Iwamoto, Makoto Watanabe, Sayoko Ogura, Kazunori Otsui, Haruo Matsuda, Kagehiro Uchida, Ryo Yoshimoto, Tatsuya Sawamura. LOX index, a novel predictive biochemical marker for coronary heart disease and stroke, Clinical Chemistry, vol. 56, no. 4, pp. 550-558, Mar. 2009.
• Yoshiko Fujita, Akemi Kakino, Norihisa Nishimichi, Saburo Yamaguchi, Yuko Sato, Sachiko Machida, Luciano Cominacini, Yves Delneste, Haruo Matsuda, Tatsuya Sawamura. Oxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects, Clinical Chemistry, vol. 55, no. 2, pp. 285-294, Feb. 2009.
• Yuko Sato, Norihisa Nishimichi, Atsushi Nakano, Kenji Takikawa, Nobutaka Inoue, Haruo Matsuda, Tatsuya Sawamura. Determination of LOX-1-ligand activity in mouse plasma with a chicken monoclonal antibody for ApoB, Atherosclerosis, vol. 200, no. 2, pp. 303-309, Oct. 2008.
• Yuko Sato, Takashi Baba, Mohamad Zubair, Kanako Miyabayashi, Yoshiro Toyama, Mamiko Maekawa, Akiko Owaki, Hirofumi Mizusaki, Tatsuya Sawamura, Kiyotaka Toshimori, Ken‐Ichirou Morohashi, Yuko Katoh‐Fukui. Importance of forkhead transcription factor Fkhl18 for development of testicular vasculature, Molecular reproduction and development, vol. 75, no. 9, pp. 1361-1371, Sept. 2008.

著書

• Hiroshi Kimura, Yuko Sato. DNA replication and histone modification, DNA Replication, Recombination, and Repair: Molecular Mechanisms and Pathology, pp. 469-488, 2016.

国際会議発表 (査読有り)

• Satoshi Uchino, Yuma Ito, Jessica Dai, Yuko Sato, Tetsuya Handa, Yasuyuki Ohkawa, Makio Tokunaga, Hiroshi Kimura. Live imaging of the initiation and elongation forms of RNA polymerase II using phosphorylation-specific probes., The 30th Hot Spring Harbor International Symposium(Online), Jan. 2022.
• Yuko Sato, Lennart Hilbert, Vasily Zaburdaev, Nadine Vastenhouw, Hiroshi Kimura. Histone modification dynamics during zygotic genome activation, International Symposium for Female Researchers in Chromatin Biology 2019, June 2019.

国内会議発表 (査読有り)

• Shuntaro Sato, Yuma Ito, Yuko Sato, Hiroshi Kimura, Makio Tokunaga. Single-molecule imaging of post-translational modification using genetically encoded antibody probe., The 56th Annual Meeting of the Biophysical Society of Japan, Sept. 2018.

国際会議発表 (査読なし・不明)

• Yuko Sato, Satoshi Uchino, Hiroshi Kimura. Chromatin mobility of X-linked loci and its transcription regulation, The 30th Hot Spring Harbor International Symposium, Jan. 2022.
• Yuko Sato, Hiroshi Kimura. Zygotic genome activation is dynamically mediated by histone acetylation in zebrafish, Cold Spring Harbor Laboratory Meeting “Nuclear Organization & Function”, May 2018.
• Hilbert, L., Yuko Sato, Kimura, H., Julicher, F., Honigmann, A., Zaburdaev, V., Vastenhouw, N.. Interphase chromatin is adaptively folded by ongoing transcription and RNA accumulation., ASCB/EMBO Meeting, MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, Vol. 28, 2017.
• Handoko, L., Chang, J., Kaczkowski, B., Fujita, K., Lizio, M., Yuko Sato, Wakamori, M., Kimura, H., Taniguchi, Y., Yanagida, T., Umehara, T., Minoda, A.. Studying combinatorial histone modifications, Annual Meeting of the American-Society-for-Cell-Biology (ASCB), MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, Vol. 27, 2016.

国内会議発表 (査読なし・不明)

• Yuko Sato, Hiroshi Kimura. Transcriptional regulation and chromatin modifications during zebrafish zygotic genome activation., 第45回日本分子生物学会年会, Dec. 2022.
• 上田 宏, DAI YANCEN, 佐藤 優子, 朱 博, 北口 哲也, 木村 宏, Farid J. Ghadessy. 生細胞内タンパク質の動態観察とそれによる細胞分別が可能な蛍光抗体プローブIntra Q-bodyの構築, 第16回バイオ関連化学シンポジウム 要旨集, Sept. 2022.
• Yuko Sato, Yuma Ito, Satoshi Uchino, Makio Tokunaga, Hiroshi Kimura. Chromatin mobility of X-linked loci and its epigenetic regulation, 第60回日本生物物理学会年会, Sept. 2022.
• 佐藤優子, 内野哲志, 岡翔平, 木村宏. 小分子抗体プローブを用いたエピジェネティクス修飾動態の生細胞イメージング, 第78回 日本顕微鏡学会学術講演会, May 2022.
• Yancen Dai, Bo Zhu, Yuko Sato, Hiroshi Kimura, Farid J. Ghadessy, Tetsuya Kitaguchi, Hiroshi Ueda.. Development of an immunofluorescence probe Q-body for the direct visualization of tumor marker p53 in fixed and living cells., 化学工学会第87年会, 化学工学会第87年会要旨集, Mar. 2022.
• 内野 哲志, 伊藤 由馬, 佐藤 優子, 半田 哲也, 大川 恭行, 徳永 万喜洋, 木村 宏. リン酸化型RNAポリメラーゼII可視化プローブによる転写部位の生細胞観察, 第39回染色体ワークショップ・第20回核ダイナミクス研究会, オンライン, Dec. 2021.
• 内野 哲志, 伊藤 由馬, Jessica Dai, 佐藤 優子, 半田 哲也, 大川 恭行, 徳永 万喜洋, 木村 宏. 転写伸長型RNAポリメラーゼII可視化プローブによる生細胞内における 転写伸長部位の観察, 第44回日本分子生物学会年会, Dec. 2021.
• 佐藤優子, 内野哲志, 伊藤由馬, 前原一満, 大川恭行, 徳永万喜洋, 木村宏. 生細胞プローブを用いた不活性化X染色体動態と転写制御の解析, 第94回 日本生化学会大会, Nov. 2021.
• Yuko Sato, Nguyen Thi Bich Ngoc, Haruka Oda, Tetsuya Handa, Hidenori Nishihara, Akihito Harada, Yasuyuki Ohkawa, Hiroshi Kimura. Spatiotemporal dynamics of histone modifications during zebrafish zygotic genome activation, 第43回日本分子生物学会年会, Dec. 2020.
• 佐藤優子, 木村宏. Xist RNAの生細胞動態解析, 第93回日本生化学会大会, Sept. 2020.
• 佐藤優子, 木村宏. 細胞内抗体Mintbodyを用いた生細胞エピジェネティクス解析, 日本エピジェネティクス研究会年会, May 2018.
• Hilbert, Lennart, Yuko Sato, Hiroshi Kimura, Honigmann, Alf, Zaburdaev, Vasily, Vastenhouw, Nadine. Transcription Locally Disperses Chromatin and Thereby Organizes the Global Architecture of Interphase Nuclei, 58th Annual Meeting of the Biophysical-Society, BIOPHYSICAL JOURNAL, CELL PRESS, Vol. 112, No. 3, pp. 211A-211A, Feb. 2017.

その他の論文・著書など

• 佐藤優子, 木村宏. 生きた細胞でクロマチン修飾変化を見る Mintbody, 実験医学別冊「クロマチン解析実践プロトコール」, pp. 233-240, Dec. 2020.
• 趙 寧, 森崎達也, 小田春佳, 佐藤優子, 木村 宏, Stasevich Timothy J. タンパク質1分子を翻訳過程からイメージング可能なプローブ「HA Frankenbody」, 実験医学, No. 38, pp. 613－617, Feb. 2020.
• 佐藤優子, 木村宏. 遺伝子不活性化マークを生細胞で観察できる蛍光プローブ, 化學工業, Vol. 69, No. 8, pp. 589－594, Aug. 2018.
• 木村宏, 佐藤優子. 遺伝子発現の理解と制御のための「ヌクレオーム」研究とエピゲノム編集, JATAFFジャーナル, Vol. 7, No. 5, pp. 3－6, Nov. 2017.
• 木村宏, 佐藤優子. ゲノム，エピゲノムからヌクレオームへ：遺伝情報発現制御機構の包括的理解に向けて, 情報管理, 国立研究開発法人 科学技術振興機構, Vol. 60, No. 8, pp. 555-563, 2017.

特許など

• 木村宏, 佐藤優子, 大井彰人, 胡桃坂　仁志, 鯨井　智也, 大川　恭行. ヒストンＨ３トリメチル化リシン特異的モノクローナル抗体又はその抗原結合性断片. 特許. 公開. 国立大学法人東京工業大学. 2017/06/06. 特願2017-111580. 2020/08/27. 特開2020-127366. 2020.
• 木村宏, 半田哲也, 佐藤優子, 林　陽子, 大川　恭行　, 原田　哲仁　, 胡桃坂　仁志　. ＤＮＡ結合タンパク質の結合領域の近傍に所望のＤＮＡ断片を挿入する方法. 特許. 登録. 国立大学法人東京工業大学, 国立大学法人九州大学. 2017/05/24. 特願2018-536938. 2019/08/08. 再表2018/042776. 特許第6943376号. 2021/09/13 2021.

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