論文

• Imai Kyosuke, Kyohei Muguruma, Ambara R. Pradipta, Katsunori Tanaka. In vivo synthetic anticancer approach by resourcing mouse blood albumin as a biocompatible artificial metalloenzyme, Angewandte Chemie International Edition, July 2024.
• Minagi Mukaiyama, Chihiro Uchiyama, Akane Fukuda, Yoshiki Nakazawa, Yuka Kuramochi, Yudai Shibata, Sho Konno, Kyohei Muguruma, Naohiro Matsugaki, Tomo Asari, Kazuyoshi Ogawa, Akihiro Taguchi, Kentaro Takayama, Atsuhiko Taniguchi, Yoko Nagumo, Toshiya Senda, Yoshio Hayashi, Takeo Usui. X-Ray Conformation and Structure–Activity Relationships of MA026, a Reversible Tight Junction Opener, Journal of Medicinal Chemistry, July 2023.  公式リンク  
  
• Yudai Ode, Ambara R. Pradipta, Peni Ahmadi, Akihiro Ishiwata, Akiko Nakamura, Yasuko Egawa, Yuriko Kusakari, Kyohei Muguruma, Yang Wang, Xiaojie Yin, Nozomi Sato, Hiromitsu Haba, Katsunori Tanaka. Therapeutic efficacy of 211At-radiolabeled 2,6-diisopropylphenyl azide in mouse models of human lung cancer, Chemical Science, June 2023.  公式リンク  
  
• Tsung-Che Chang, Igor Nasibullin, Kyohei Muguruma, Yuriko Kusakari, Taiji Shimoda, Katsunori Tanaka. Evaluation of acute toxicity of cancer-targeting albumin-based artificial metalloenzymes, Bioorganic & Medicinal Chemistry, Nov. 2022.  公式リンク  
  
• Ahmadi P, Muguruma K, Chang TC, Tamura S, Tsubokura K, Egawa Y, Suzuki T, Dohmae N, Nakao Y, Tanaka K. In vivo metal-catalyzed SeCT therapy by a proapoptotic peptide., Chemical science, Sept. 2021.  公式リンク  
  
• Pradipta AR, Ahmadi P, Terashima K, Muguruma K, Fujii M, Ichino T, Maeda S, Tanaka K. Targeted 1,3-dipolar cycloaddition with acrolein for cancer prodrug activation., Chemical science, Apr. 2021.  公式リンク  
  
• Muguruma K, Osawa R, Fukuda A, Ishikawa N, Fujita K, Taguchi A, Takayama K, Taniguchi A, Ito Y, Hayashi Y. Development of a High-Affinity Antibody-Binding Peptide for Site-Specific Modification., ChemMedChem, Mar. 2021.  公式リンク  
  
• Sasaki K, Muguruma K, Osawa R, Fukuda A, Taniguchi A, Kishimura A, Hayashi Y, Mori T, Katayama Y. Synthesis and biological evaluation of a monocyclic Fc-binding antibody-recruiting molecule for cancer immunotherapy., RSC medicinal chemistry, Jan. 2021.  公式リンク  
  
• Muguruma K, Pradipta AR, Ode Y, Terashima K, Michiba H, Fujii M, Tanaka K. Disease-associated acrolein: A possible diagnostic and therapeutic substrate for in vivo synthetic chemistry., Bioorganic & medicinal chemistry, Oct. 2020.  公式リンク  
  
• Muguruma K, Ito M, Fukuda A, Kishimoto S, Taguchi A, Takayama K, Taniguchi A, Ito Y, Hayashi Y. Synthesis and structure-activity relationship studies of IgG-binding peptides focused on the C-terminal histidine residue., MedChemComm, Aug. 2019.  公式リンク  
  
• Muguruma K, Fujita K, Fukuda A, Kishimoto S, Sakamoto S, Arima R, Ito M, Kawasaki M, Nakano S, Ito S, Shimizu K, Taguchi A, Takayama K, Taniguchi A, Hayashi Y. Kinetics-Based Structural Requirements of Human Immunoglobulin G Binding Peptides., ACS omega, Aug. 2019.  公式リンク  
  
• Muguruma K, Shirasaka T, Akiyama D, Fukumoto K, Taguchi A, Takayama K, Taniguchi A, Hayashi Y. An Efficient Method for the Conjugation of Hydrophilic and Hydrophobic Components by Solid-Phase-Assisted Disulfide Ligation., Angewandte Chemie (International ed. in English), Jan. 2018.  公式リンク  
  
• Takayama K, Rentier C, Asari T, Nakamura A, Saga Y, Shimada T, Nirasawa K, Sasaki E, Muguruma K, Taguchi A, Taniguchi A, Negishi Y, Hayashi Y. Development of Potent Myostatin Inhibitory Peptides through Hydrophobic Residue-Directed Structural Modification., ACS medicinal chemistry letters, June 2017.  公式リンク  
  
• Taguchi A, Kobayashi K, Kotani A, Muguruma K, Kobayashi M, Fukumoto K, Takayama K, Hakamata H, Hayashi Y. 3-Nitro-2-pyridinesulfenates as Efficient Solution- and Solid-Phase Disulfide Bond Forming Agents., Chemistry (Weinheim an der Bergstrasse, Germany), May 2017.  公式リンク  
  
• Yakushiji F, Muguruma K, Hayashi Y, Shirasaka T, Kawamata R, Tanaka H, Yoshiwaka Y, Taguchi A, Takayama K, Hayashi Y. Click strategy using disodium salts of amino acids improves the water solubility of plinabulin and KPU-300., Bioorganic & medicinal chemistry, May 2017.  公式リンク  
  
• Muguruma K, Yakushiji F, Kawamata R, Akiyama D, Arima R, Shirasaka T, Kikkawa Y, Taguchi A, Takayama K, Fukuhara T, Watabe T, Ito Y, Hayashi Y. Novel Hybrid Compound of a Plinabulin Prodrug with an IgG Binding Peptide for Generating a Tumor Selective Noncovalent-Type Antibody-Drug Conjugate., Bioconjugate chemistry, July 2016.  公式リンク  
  
• Hayashi Y, Takeno H, Chinen T, Muguruma K, Okuyama K, Taguchi A, Takayama K, Yakushiji F, Miura M, Usui T, Hayashi Y. Development of a new benzophenone-diketopiperazine-type potent antimicrotubule agent possessing a 2-pyridine structure., ACS medicinal chemistry letters, July 2014.  公式リンク  
  
• Yakushiji F, Tanaka H, Muguruma K, Iwahashi T, Yamazaki Y, Hayashi Y. Water-soluble prodrug of antimicrotubule agent plinabulin: effective strategy with click chemistry., Chemistry (Weinheim an der Bergstrasse, Germany), Sept. 2011.  公式リンク  
  

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