論文

• Haruka Kono, Satoshi Hara, Tadaomi Furuta, Hiroshi Ichinose. Binding profile of quinonoid-dihydrobiopterin to quinonoid-dihydropteridine reductase examined by in silico and in vitro analyses, J Biochem, vol. 174, no. 5, pp. 441-450, Aug. 2023.
• Tschaffon-Muller MEA, Kempter E, Steppe L, Kupfer S, Kuhn MR, Gebhard F, Pankratz C, Kalbitz M, Schutze K, Gundel H, Kaleck N, Strauss G, Vacher J, Ichinose H, Weimer K, Ignatius A, Haffner-Luntzer M, Reber SO. Neutrophil-derived catecholamines mediate negative stress effects on bone, Nature Communications, June 2023.
• Yuka Nago-Iwashita, Moriya Y, Hara S, Ogawa R, Aida R, Miyajima K, Shimura T, Muramatsu SI, Ide S, Ikeda K, Ichinose H. Overexpression of tyrosine hydroxylase in dopaminergic neurons increased sensitivity to methamphetamine, Neurochemistry International, Vol. 164, pp. 105491, Apr. 2023.
• Suganuma Y, Sumi-Ichinose C, Kano T, Ikemoto K, Matsui T, Ichinose H, Kondo K. Quinonoid dihydropteridine reductase, a tetrahydrobiopterin-recycling enzyme, contributes to 5-hydroxytryptamine-associated platelet aggregation in mice, Journal of Pharmacological Sciences, Vol. 150, Issue 3, pp. 173-179, Nov. 2022.
• Madokoro Y, Kamikokuryo C, Niiyama S, Ito T, Hara S, Ichinose H, Kakihana Y. Early ascorbic acid administration prevents vascular endothelial cell damage in septic mice, Front Pharmacol, Vol. 13, 929448, Oct. 2022.
• Kuhn MR, Haffner-Luntzer M, Kempter E, Reber SO, Ichinose H, Vacher J, Ignatius A, Tschaffon-Muller MEA. Myeloid cell-derived catecholamines influence bone turnover and regeneration in mice, Front Endocrinol (Lausanne), Vol. 13, Page 997745, Sept. 2022.
• C. Sumi-Ichinose, Y. Suganuma, T. Kano, K. Ikemoto, N. Ihira, H. Ichinose, K. Kondo. Priapism caused by partial deficiency of tetrahydrobiopterin through hypofunction of the sympathetic neurons in sepiapterin reductase gene-disrupted mice, J INHERIT METAB DIS, Wiley, Vol. 45, no. 3, 621-634, May 2022.
• Hara S, Sanatani T, Tachikawa N, Yoshimura Y, Miyata N, Sasaki H, Kuroda R, Kamikokuryo C, Eguchi T, Niiyama S, Kakihana Y, Ichinose H.. Comparison of the levels of neopterin, CRP, and IL-6 in patients infected with and without SARS-CoV-2., Heliyon, Volume 8, Issue 5, e09371, May 2022.
• Miyajima K, Sudo Y, Sanechika S, Hara Y, Horiguchi M, Xu F, Suzuki M, Hara S, Tanda K, Inoue KI, Takada M, Yoshioka N, Takebayashi H, Mori-Kojima M, Sugimoto M, Sumi-Ichinose C, Kondo K, Takao K, Miyakawa T, Ichinose H.. Perturbation of monoamine metabolism and enhanced fear responses in mice defective in the regeneration of tetrahydrobiopterin, Journal of neurochemistry, Volume 161, Issue 2, Page 129-145, May 2022.
• Sumi-Ichinose C, Suganuma Y, Kano T, Ikemoto K, Ihira N, Ichinose H, Kondo K. Priapism caused by partial deficiency of tetrahydrobiopterin through hypofunction of the sympathetic neurons in sepiapterin reductase gene-disrupted mice, J Inherit Metab Dis, vol. 45, 621-634, May 2022.
• Inukai S, Hara S, Ichinose H.. Tyrosine hydroxylase activity is regulated through the modification of the 176th cysteine residue, Biochem Biophys Res Commun., Volume 589, Page 209-214, Jan. 2022.
• Miyajima K, Kawamoto C, Hara S, Mori-Kojima M, Ohye T, Sumi-Ichinose C, Saito N, Sasaoka T, Metzger D, Ichinose H. Tyrosine hydroxylase conditional knockout mice reveal peripheral tissue-dependent differences in dopamine biosynthetic pathways, Vol. 296, Page 100544, May 2021.
• Yang P, Tian H, Zou YR, Chambon P, Ichinose H, Honig G, Diamond B, Kim SJ. Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis, Vol. 12, Page 616583, Feb. 2021.
• Kawai F, Ohkuma M, Horiguchi M, Ichinose H, Miyachi E.I.. A subset of cone bipolar cells expresses the Na(+) channel SCN2A in the human retina, Experimental Eye Research, Elseviier, Vol. 202, p. 108299, Jan. 2021.
• hirokazu arai, rina takahashi, yoshiaki sakamoto, tatsuya kitano, okishi mashita, satoshi hara, satoru yoshikawa, koh kawasaki, hiroshi ichinose. Peripheral tetrahydrobiopterin is involved in the pathogenesis of mechanical hypersensitivity in a rodent postsurgical pain model, Pain, June 2020.
• Zhang L, Hara S, Ichinose H, Nagashima D, Morita K, Sakurai T, Ichihara S, Ichihara G.. Exposure to acrylamide decreases noradrenergic axons in rat brain., NEUROTOXICOLOGY, May 2020.
• Takeshita N, Kawade N, Suzuki W, Hara S, Horio F, Ichinose H. Deficiency of ascorbic acid decreases the contents of tetrahydrobiopterin in the liver and the brain of ODS rats., Neuroscience letters, Jan. 2020.
• Miramontes-Gonzalez JP, Hightower M, Zhang K, Kurosaki H, Schork AJ, Biswas N, Vaingankar S, Mahata M, Lipkowitz MS, Nievergelt CM, Baker DG, Ziegler MG, Leon-Jimenez D, Gonzalez-Sarmiento R, Ichinose H, O'Connor DT. A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function., Scientific Reports, 9, 1, 5055, Mar. 2019.
• Hara S, Fukumura S, Ichinose H. Reversible S-glutathionylation of human 6-pyruvoyl tetrahydropterin synthase protects its enzymatic activity, Journal of Biological Chemistry, Vol. 394, No. 4, Page 1420-1427, Jan. 2019.
• Jin F, Li X, Deng Y, Timilshina M, Huang B, Kim DY, Chang JH, Ichinose H, Baek SH, Murakami M, Lee YJ, Chang HW. The orphan nuclear receptor NR4A1 promotes FcepsilonRI-stimulated mast cell activation and anaphylaxis by counteracting the inhibitory LKB1/AMPK axis., Allergy, 74, 6, 1145-1156, Dec. 2018.
• 宮嶋克也, 原怜, 一瀬宏. 葉酸代謝はオリゴデンドロサイトの分化や生存を制御している, Vol. 92, No. 10, p. 464-465, Oct. 2018.
• Tel-Karthaus N, Kers-Rebel ED, Looman MW, Ichinose H, de Vries CJ, Ansems M. Nuclear Receptor Nur77 Deficiency Alters Dendritic Cell Function., Frontiers in Immunology, 9, 1797, Aug. 2018.
• Toshiharu Nagatsu, Akira Nakashima, Hiroshi Ichinose, Kazuto Kobayashi. Human tyrosine hydroxylase in Parkinson's disease and in related disorders., J Neural Transm, Springer, 126, 4, 397-409, July 2018.
• Hiroshi Ichinose, Ken-ichi Inoue, Shinobu Arakawa, Yuki Watanabe, Hiroki Kurosaki, Shoko Koshiba, Eldbjorg Hustad, Masahiko Takada, Jan O. Aasly. Alterations in the reduced pteridine contents in the cerebrospinal fluids of LRRK2 mutation carriers and patients with Parkinson's disease., Journal of neural transmission, Springer, Sept. 2017.  公式リンク  
  
• Motokazu Koga, Anna Sezaki, Yuka Nakao, Yuji Kamikubo, Tatsuo Hashimoto, Yuki Okuyama-Oki, Aderemi Caleb Aladeokin, Fumio Nakamura, Utako Yokoyama, Hiromichi Wakui, Hiroshi Ichinose, Takashi Sakurai, Satoshi Umemura, Koichi Tamura, Yoshihiro Ishikawa, Yoshio Goshima. L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor., JCI insight, vol. 2, no. 18, 90903, Sept. 2017.  公式リンク  
  
• 竹下直輝, 原怜, 一瀬宏. キサンツレン酸はビオプテリン生合成酵素の阻害作用を持つ, ビタミン, Vol. 91, No. 5, 6, p. 361-362, June 2017.
• Tobias Rothe, Natacha Ipseiz, Maria Faas, Stefanie Lang, Francesc Perez-Branguli, Daniel Metzger, Hiroshi Ichinose, Beate Winner, Georg Schett, Gerhard Krönke. The Nuclear Receptor Nr4a1 Acts as a Microglia Rheostat and Serves as a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation, The Journal of Immunology, Apr. 2017.
• Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Hiroko Nomura, Kazuhisa Ikemoto, Tadayoshi Hata, Setsuko Katoh, Hiroshi Ichinose, Kazunao Kondo. Sepiapterin reductase gene-disrupted mice suffer from hypertension with fluctuation and bradycardia., Physiological reports, vol. 5, No. 6, e13196, Mar. 2017.  公式リンク  
  
• Keiko Imamura, Takayuki Kondo, Yasushi Koshiba, Satoshi Hara, Hiroshi Ichinose, Mahoko Furujo, Masako Kinoshita, Tomoko Oeda, Jun Takahashi, Ryosuke Takahashi, Haruhisa Inoue. Genetic and pharmacological correction of aberrant dopamine synthesis using patient iPSCs with BH4 metabolism disorders., Human Molecular Genetics, Vol. 25, No. 23, pp. 5188-5197, Dec. 2016.  公式リンク  
  
• 加藤北都, 原怜, 一瀬宏. パーキンソン病動物モデルにおけるイソチオシアネートの神経保護作用について, ビタミン, vol. 90, No. 7, pp. 350-352, July 2016.
• Hiroshi Ichinose. Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice., Journal of Inherited Metabolic Disease, Mar. 2016.  公式リンク  
  
• Hanna RN, Cekic C, Sag D, Tacke R, Thomas GD, Nowyhed H, Herrley E, Rasquinha N, McArdle S, Wu R, Peluso E, Metzger D, Ichinose H, Shaked I, Chodaczek G, Biswas SK, Hedrick CC. Patrolling monocytes control tumor metastasis to the lung., Science, 350, 6263, 985-990, Oct. 2015.  公式リンク  
  
• Ichiro Kawahata, Shiori Ohtaku, Yoshihisa Tomioka, Hiroshi Ichinose, Tohru Yamakuni. Dopamine or biopterin deficiency potentiates phosphorylation at (40)Ser and ubiquitination of tyrosine hydroxylase to be degraded by the ubiquitin proteasome system, Biochem Biophys Res Commun, Vol. 465, No. 1, pp. 53-58, Sept. 2015.  公式リンク  
  
• Sekiya T, Kondo T, Shichita T, Morita R, Ichinose H, Yoshimura A. Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells., J. Exp. Med., 212, 1623-1640, Sept. 2015.  公式リンク  
  
• Sugiura K, Nagai T, Nakano M, Ichinose H, Nakabayashi T, Ohta N, Hisabori T. Redox sensor proteins for highly sensitive direct imaging of intracellular redox state., Biochem. Biophys. Res. Commun., Vol. 457, pp. 242-248, Feb. 2015.  公式リンク  
  
• Feng Xu, Yusuke Sudo, Sho Sanechika, Junpei Yamashita, Sho Shimaguchi, Shun-ichiro Honda, Chiho Sumi-Ichinose, Masayo Mori-Kojima, Rieko Nakata, Tadaomi Furuta, Minoru Sakurai, Masahiro Sugimoto, Tomoyoshi Soga, Kazunao Kondo, Hiroshi Ichinose. Disturbed biopterin and folate metabolism in the Qdpr-deficient mouse, FEBS Lett., vol. 588, no. 21, pp. 3924-3931, Nov. 2014.
• Abe, J., Nakamura, K., Nishikomori, R., Kato, M., Mitsuiki, N., Izawa, K., Awaya, T., Kawai, T., Yasumi, T., Toyoshima, I., Hasegawa, K., Ohshima, Y., Hiragi, T., Sasahara, Y., Suzuki, Y., Kikuchi, M., Osaka, H., Ohya, T., Ninomiya, S., Fujikawa, S., Akasaka, M., Iwata, N., Kawakita, A., Funatsuka, M., Shintaku, H., Ohara, O., Hiroshi Ichinose, Heike, T.. A nationwide survey of Aicardi-Goutières syndrome patients identifies a strong association between dominant TREX1 mutations and chilblain lesions: Japanese cohort study, Rheumatology (Oxford), Vol. 53, No. 3, pp. 448-458, Mar. 2014.  公式リンク  
  
• Tokuoka, H., Hatanaka, T., Metzger, D., Hiroshi Ichinose. Nurr1 expression is regulated by voltage-dependent calcium channels and calcineurin in cultured hippocampal neurons, Neuroscience Letters, Vol. 559, pp. 50-55, 2014.  公式リンク  
  
• Horiguchi, M., Ohi, K., Hashimoto, R., Hao, Q., Yasuda, Y., Yamamori, H., Fujimoto, M., Umeda-Yano, S., Takeda, M., Hiroshi Ichinose. Functional polymorphism (C-824T) of the tyrosine hydroxylase gene affects IQ in schizophrenia, Psychiatry and Clinical Neurosciences, Vol. 68, No. 6, pp. 456-462, 2014.  公式リンク  
  
• Yasuda, Y., Hashimoto, R., Ohi, K., Yamamori, H., Fujimoto, M., Umeda-Yano, S., Fujino, H., Fukunaga, M., Horiguchi, M., Takeda, M., Hiroshi Ichinose. A functional polymorphism of the GTP cyclohydrolase 1 gene predicts attention performance, Neuroscience Letters, Vol. 566, pp. 46-49, 2014.  公式リンク  
  
• 一瀬宏. ビオプテリンの生理機能と病態代謝, ビタミン, 公益社団法人 日本ビタミン学会, Vol. 88, No. 3, pp. 131-138, 2014.
• 村上 てるみ, 西村 敏, 舟塚 真, 新宅 治夫, 一瀬宏, 大澤 眞木子. 脳性麻痺と診断されていた瀬川病の女性例, 東京女子医科大学雑誌, 東京女子医科大学, Vol. 83, No. 3, pp. E663-E665, July 2013.
• S. Fukuda, M. Horiguchi, K. Yamaguti, Y. Nakatomi, H. Kuratsune, H. Ichinose, Y. Watanabe. Association of monoamine-synthesizing genes with the depression tendency and personality in chronic fatigue syndrome patients, Life Sciences, Vol. 92, No. 3, pp. 183-186, 2013.  公式リンク  
  
• I.A. Armata, L. Balaj, J.K. Kuster, X. Zhang, S. Tsai, A.A. Armatas, T.J. Multhaupt-Buell, R. Soberman, X.O. Breakefield, H. Ichinose, N. Sharma. Dopa-Responsive Dystonia: Functional Analysis of Single Nucleotide Substitutions within the 5' Untranslated GCH1 Region, PLoS ONE, Vol. 8, No. 10, 2013.  公式リンク  
  
• 一瀬宏. パントテン酸キナーゼ遺伝子の欠損で発症する神経変性疾患NBIA1, ビタミン, 公益社団法人 日本ビタミン学会, Vol. 87, No. 7, pp. 399-401, 2013.
• T. Sekiya, I. Kashiwagi, R. Yoshida, T. Fukaya, R. Morita, A. Kimura, H. Ichinose, D. Metzger, P. Chambon, A. Yoshimura. Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis, Nature Immunology, 14, 3, 230-237, 2013.  公式リンク  
  
• N.-C. Lee, Y.-D. Shieh, Y.-H. Chien, K.-Y. Tzen, I.-S. Yu, P.-W. Chen, M.-H. Hu, M.-K. Hu, S.-I. Muramatsu, H. Ichinose, W.-L. Hwu. Regulation of the dopaminergic system in a murine model of aromatic l-amino acid decarboxylase deficiency, Neurobiology of Disease, Vol. 52, pp. 177-190, 2013.  公式リンク  
  
• Y. Liang, H. Inagaki, Q. Hao, M. Sakamoto, T. Ohye, T. Suzuki, H. Ichinose. Identification of an enhancer region for immune activation in the human GTP cyclohydrolase i gene, Biochemical and Biophysical Research Communications, Vol. 442, No. 1-2, pp. 72-78, 2013.  公式リンク  
  
• W.-L. Hwu, N.-C. Lee, Y.-H. Chien, S.-I. Muramatsu, H. Ichinose. AADC deficiency. Occurring in humans, modeled in rodents., Advances in Pharmacology, Vol. 68, pp. 273-284, 2013.  公式リンク  
  
• D. Homma, S. Katoh, H. Tokuoka, H. Ichinose. The role of tetrahydrobiopterin and catecholamines in the developmental regulation of tyrosine hydroxylase level in the brain, Journal of Neurochemistry, Vol. 126, No. 1, pp. 70-81, 2013.  公式リンク  
  
• D. Homma, J.P. Kondo, S. Katoh, H. Ichinose. Tetrahydrobiopterin Deficiency Impairs Postnatal Increase of TH Protein via Insufficient Dopamine Biosynthesis, Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012, 2013.  公式リンク  
  
• T. Toda, D. Homma, H. Tokuoka, I. Hayakawa, Y. Sugimoto, H. Ichinose, H. Kawasaki. Birth Regulates the Initiation of Sensory Map Formation through Serotonin Signaling, Developmental Cell, Vol. 27, No. 1, pp. 32-46, 2013.  公式リンク  
  
• T. Kishi, H. Ichinose, R. Yoshimura, Y. Fukuo, T. Kitajima, T. Inada, H. Kunugi, T. Kato, T. Yoshikawa, H. Ujike, G.M. Musso, W. Umene-Nakano, J. Nakamura, N. Ozaki, N. Iwata. GTP cyclohydrolase 1 gene haplotypes as predictors of SSRI response in Japanese patients with major depressive disorder, Journal of Affective Disorders, Vol. 142, No. 1-3, pp. 315-322, 2012.  公式リンク  
  
• T. Kanao, T. Sawada, S.-A. Davies, H. Ichinose, K. Hasegawa, R. Takahashi, N. Hattori, Y. Imai. The nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in drosophila, PLoS ONE, Vol. 7, No. 2, 2012.  公式リンク  
  
• H. Yagi, S. Sanechika, H. Ichinose, C. Sumi-Ichinose, H. Mizukami, M. Urabe, K. Ozawa, A. Kume. Recovery of neurogenic amines in phenylketonuria mice after liver-targeted gene therapy, NeuroReport, Vol. 23, No. 1, pp. 30-34, 2012.  公式リンク  
  
• Tokuoka H, Muramatsu S, Sumi-Ichinose C, Sakane H, Kojima M, Aso Y, Nomura T, Metzger D, Ichinose H.. Compensatory Regulation of Dopamine after Ablation of the Tyrosine Hydroxylase Gene in the Nigrostriatal Projection, J Biol Chem., Vol. 286, No. 50, p. 43549-43558, Dec. 2011.
• Koshiba S, Tokuoka H, Yokoyama T, Horiuchi E, Ichinose H, Hasegawa K. Biopterin levels in the cerebrospinal fluid of patients with PARK8 (I2020T), J Neural Transm, Feb. 2011.
• Homma D, Sumi-Ichinose C, Tokuoka H, Ikemoto K, Nomura T, Kondo K, Katoh S, Ichinose H. Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain, J Biol Chem, 286, 1445-1452, Jan. 2011.
• T. Sekiya, I. Kashiwagi, N. Inoue, R. Morita, S. Hori, H. Waldmann, A.Y. Rudensky, H. Ichinose, D. Metzger, P. Chambon, A. Yoshimura. The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells, Nature Communications, Vol. 2, No. 1, 2011.  公式リンク  
  
• 一瀬宏, 小柴 梢子, 本田 俊一郎, 徳岡 宏文. ビオプテリン測定の現状と課題(ビタミン測定法の現状と課題[V]), ビタミン, 公益社団法人 日本ビタミン学会, Vol. 85, No. 10, pp. 547-551, 2011.
• C. Sumi-Ichinose, H. Ichinose, K. Ikemoto, T. Nomura, K. Kondo. Advanced research on dopamine signaling to develop drugs for the treatment of mental disorders: Regulation of dopaminergic neural transmission by tyrosine hydroxylase protein at nerve terminals, Journal of Pharmacological Sciences, Vol. 114, No. 1, pp. 17-24, 2010.  公式リンク  
  
• M. Fukuchi, H. Fujii, H. Takachi, H. Ichinose, Y. Kuwana, A. Tabuchi, M. Tsuda. Activation of tyrosine hydroxylase (TH) gene transcription induced by brain-derived neurotrophic factor (BDNF) and its selective inhibition through Ca2+ signals evoked via the N-methyl-d-aspartate (NMDA) receptor, Brain Research, Vol. 1366, pp. 18-26, 2010.  公式リンク  
  
• H. Yagi, S. Sanechika, H. Ichinose, H. Mizukami, T. Ogura, M. Urabe, H. Hamada, H. Yoshikawa, K. Ozawa, A. Kume. LIVER-TARGETED GENE THERAPY WITH A SELF-COMPLEMENTARY AAV AMELIORATED BRAIN AMINERGIC DEFICIT IN PHENYLKETONURIA MICE, Journal of Gene Medicine, Vol. 12, No. 12, pp. 1061-1061, 2010.  公式リンク  
  
• Kawahata I, Tokuoka H, Parvez H, Ichinose H. Accumulation of phosphorylated tyrosine hydroxylase into insoluble protein aggregates by inhibition of an ubiquitin–proteasome system in PC12D cells, Journal of Neural Transmission, Springer Wien, Vol. 116, No. 12, pp. 1571-1578, Dec. 2009.
• Ichiro Kawahata, Saburo Yagishita, Kazuko Hasegawa, Ikuko Nagatsu, Toshiharu Nagatsu, Hiroshi Ichinose. Immunohistochemical analyses of the postmortem human brains from patients with Parkinson’s disease with anti-tyrosine hydroxylase antibodies, Biogenic Amines, Society of Integrated Sciences, Vol. 23, Dec. 2009.
• S. Yoshikawa, N. Hareyama, K. Ikeda, T. Kurokawa, M. Nakajima, K. Nakao, H. Mochizuki, H. Ichinose. Effects of TRK-820, a selective kappa opioid receptor agonist, on rat schizophrenia models, European Journal of Pharmacology, Vol. 606, No. 1-3, pp. 102-108, 2009.  公式リンク  
  
• B. Kadkhodaei, T. Ito, E. Joodmardi, B. Mattsson, C. Rouillard, M. Carta, S.-I. Muramatsu, C. Sumi-Ichinose, T. Nomura, D. Metzger, P. Chambon, E. Lindqvist, N.-G. Larsson, L. Olson, A. Björklund, H. Ichinose, T. Perlmann. Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons, Journal of Neuroscience, Vol. 29, No. 50, pp. 15923-15932, 2009.  公式リンク  
  
• B. Chavan, W. Beazley, J.M. Wood, H. Rokos, H. Ichinose, K.U. Schallreuter. H2O2 increases de novo synthesis of (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin via GTP cyclohydrolase I and its feedback regulatory protein in vitiligo, Journal of Inherited Metabolic Disease, Vol. 32, No. 1, pp. 86-94, 2009.  公式リンク  
  
• K. Momma, M. Funayama, Y. Li, H. Ichinose, K. Motoyoshi, N. Hattori, Y. Mizuno, K. Kamakura. A new mutation in the GCH1 gene presents as early-onset Parkinsonism, Parkinsonism and Related Disorders, Vol. 15, No. 2, pp. 160-161, 2009.  公式リンク  
  
• M. Kojima, T. Suzuki, T. Maekawa, S. Ishii, C. Sumi-Ichinose, T. Nomura, H. Ichinose. Increased expression of tyrosine hydroxylase and anomalous neurites in catecholaminergic neurons of ATF-2 null mice, Journal of Neuroscience Research, Vol. 86, No. 3, pp. 544-552, 2008.  公式リンク  
  
• C. Takazawa, K. Fujimoto, D. Homma, C. Sumi-Ichinose, T. Nomura, H. Ichinose, S. Katoh. A brain-specific decrease of the tyrosine hydroxylase protein in sepiapterin reductase-null mice-as a mouse model for Parkinson's disease, Biochemical and Biophysical Research Communications, Vol. 367, No. 4, pp. 787-792, 2008.  公式リンク  
  
• H. Ichinose, T. Nomura, C. Sumi-Ichinose. Metabolism of tetrahydrobiopterin: Its relevance in monoaminergic neurons and neurological disorders, Chemical Record, Vol. 8, No. 6, pp. 378-385, 2008.  公式リンク  
  
• K. Sato, C. Sumi-Ichinose, R. Kaji, K. Ikemoto, T. Nomura, I. Nagatsu, H. Ichinose, M. Ito, W. Sako, S. Nagahiro, A.M. Graybiel, S. Goto. Differential involvement of striosome and matrix dopamine systems in a transgenic model of dopa-responsive dystonia, Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, No. 34, pp. 12551-12556, 2008.  公式リンク  
  
• M. Shimojo, N. Sahara, T. Mizoroki, S. Funamoto, M. Morishima-Kawashima, T. Kudo, M. Takeda, Y. Ihara, H. Ichinose, A. Takashima. Enzymatic characteristics of I213T mutant presenilin-1/γ-secretase in cell models and knock-in mouse brains: Familial Alzheimer disease-linked mutation impairs γ-site cleavage of amyloid precursor protein C-terminal fragment β, Journal of Biological Chemistry, Vol. 283, No. 24, pp. 16488-16496, 2008.  公式リンク  
  
• S. Koshiba, T. Ito, A. Shiota, K. Wakabayashi, M. Ueda, H. Ichinose, T. Ishikawa. Development of polyclonal antibodies specific to ATP-binding cassette transporters human ABCG4 and mouse Abcg4: Site-specific expression of mouse Abcg4 in brain, Journal of Experimental Therapeutics and Oncology, Vol. 6, No. 4, pp. 321-333, 2007.  公式リンク  
  
• M. Shimojo, N. Sahara, M. Murayama, H. Ichinose, A. Takashima. Decreased Aβ secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1, Neuroscience Research, Vol. 57, No. 3, pp. 446-453, 2007.  公式リンク  
  
• T. Suzuki, S. Usuda, H. Ichinose, S. Inouye. Real-time bioluminescence imaging of a protein secretory pathway in living mammalian cells using Gaussia luciferase, FEBS Letters, Vol. 581, No. 24, pp. 4551-4556, 2007.  公式リンク  
  
• H. Ichinose, T. Nagatsu. Identification of the causative gene for Segawa's disease, Clinical Neurology, Vol. 47, No. 11, pp. 735-738, 2007.  公式リンク  
  
• H. Furuya, H. Murai, K. Takasugi, Y. Ohyagi, F. Urano, T. Kishi, H. Ichinose, J.-i. Kira. A case of late-onset Segawa syndrome (autosomal dominant dopa-responsive dystonia) with a novel mutation of the GTP-cyclohydrase I (GCH1) gene, Clinical Neurology and Neurosurgery, Vol. 108, No. 8, pp. 784-786, 2006.  公式リンク  
  
• X.-G. Li, T. Okada, M. Kodera, Y. Nara, N. Takino, C. Muramatsu, K. Ikeguchi, F. Urano, H. Ichinose, D. Metzger, P. Chambon, I. Nakano, K. Ozawa, S.-I. Muramatsu. Viral-mediated temporally controlled dopamine production in a rat model of Parkinson disease, Molecular Therapy, Vol. 13, No. 1, pp. 160-166, 2006.  公式リンク  
  
• S. Ogawa, H. Ichinose. Effect of metals and phenylalanine on the activity of human tryptophan hydroxylase-2: Comparison with that on tyrosine hydroxylase activity, Neuroscience Letters, Vol. 401, No. 3, pp. 261-265, 2006.  公式リンク  
  
• S. Ogawa, J. Yamashita, H. Ichinose. Characterization of recombinant human tryptophan hydroxylase-2 (hTPH2) fused to maltose-binding protein, and production of anti-hTPH2 antibody, Biogenic Amines, Vol. 20, No. 3-4, pp. 87-98, 2006.  公式リンク  
  
• E. Ohta, M. Funayama, H. Ichinose, I. Toyoshima, F. Urano, M. Matsuo, N. Tomoko, K. Yukihiko, S. Yoshino, H. Yokoyama, H. Shimazu, K. Maeda, K. Hasegawa, F. Obata. Novel mutations in the guanosine triphosphate cyclohydrolase 1 gene associated with DYT5 dystonia, Archives of Neurology, Vol. 63, No. 11, pp. 1605-1610, 2006.  公式リンク  
  
• K. Sakai, H. Suzuki, H. Oda, T. Akaike, Y. Azuma, T. Murakami, K. Sugi, T. Ito, H. Ichinose, S. Koyasu, M. Shirai. Phosphoinositide 3-kinase in nitric oxide synthesis in macrophage: Critical dimerization of inducible nitric-oxide synthase, Journal of Biological Chemistry, Vol. 281, No. 26, pp. 17736-17742, 2006.  公式リンク  
  
• Fumi Urano, Hayashi N, FUMIO ARISAKA, Hideki Kurita, Murata Shizuaki, Ichinose H. Molecular mechanism for pterin-mediated inactivation of tyrosine hydroxylase: Formation of insoluble aggregates of tyrosine hydroxylase, J.Biochem., Vol. 139, No. 4, pp. 625-635, 2006.  公式リンク  
  
• F. Kawai, M. Horiguchi, H. Ichinose, M. Ohkuma, R. Isobe, E.-I. Miyachi. Suppression by an h current of spontaneous Na+ action potentials in human cone and rod photoreceptors, Investigative Ophthalmology and Visual Science, Vol. 46, No. 1, pp. 390-397, 2005.  公式リンク  
  
• C. Sumi-Ichinose, F. Urano, A. Shimomura, T. Sato, K. Ikemoto, H. Shiraishi, T. Senda, H. Ichinose, T. Nomura. Genetically rescued tetrahydrobiopterin-depleted mice survive with hyperphenylalaninemia and region-specific monoaminergic abnormalities, Journal of Neurochemistry, Vol. 95, No. 3, pp. 703-714, 2005.  公式リンク  
  
• E. Ohta, I. Toyoshima, M. Funayama, H. Ichinose, K. Hasegawa, F. Obata. A new mutation (Thr106Ile) of the GTP cyclohydrolase 1 gene associated with DYT5 dystonia (Segawa Disease) [8], Movement Disorders, Vol. 20, No. 8, pp. 1083-1084, 2005.  公式リンク  
  
• T. Ito, T. Suzuki, H. Ichinose. Nerve growth factor-induced expression of the GTP cyclohydrolase I gene via Ras/MEK pathway in PC12D cells, Journal of Neurochemistry, Vol. 95, No. 2, pp. 563-569, 2005.  公式リンク  
  
• T. Okuno, Y. Nakatsuji, A. Kumanogoh, M. Moriya, H. Ichinose, H. Sumi, H. Fujimura, H. Kikutani, S. Sakoda. Loss of dopaminergic neurons by the induction of inducible nitric oxide synthase and cyclooxygenase-2 via CD40: Relevance to Parkinson's disease, Journal of Neuroscience Research, Vol. 81, No. 6, pp. 874-882, 2005.  公式リンク  
  
• T. Suzuki, H. Kurahashi, H. Ichinose. Ras/MEK pathway is required for NGF-induced expression of tyrosine hydroxylase gene, Biochemical and Biophysical Research Communications, Vol. 315, No. 2, pp. 389-396, 2004.  公式リンク  
  
• T. Suzuki, H. Kurita, H. Ichinose. GTP cyclohydrolase I utilizes metal-free GTP as its substrate, European Journal of Biochemistry, Vol. 271, No. 2, pp. 349-355, 2004.  公式リンク  
  
• A. Kikuchi, A. Takeda, K. Fujihara, T. Kimpara, Y. Shiga, H. Tanji, M. Nagai, H. Ichinose, F. Urano, N. Okamura, H. Arai, Y. Itoyama. Arg(184)His mutant GTP cyclohydrolase I, causing recessive hyperphenylalaninemia, is responsible for dopa-responsive dystonia with Parkinsonism: A case report, Movement Disorders, Vol. 19, No. 5, pp. 590-593, 2004.  公式リンク  
  
• H. Shiraishi, T. Kato, K. Atsuta, C. Sumi-Ichinose, M. Ohtsuki, M. Itoh, H. Hishida, S. Tada, Y. Udagawa, T. Nagatsu, Y. Hagino, H. Ichinose, T. Nomura. cGMP inhibits GTP cyclohydrolase I activity and biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells, Journal of Pharmacological Sciences, Vol. 93, No. 3, pp. 265-271, 2003.  公式リンク  
  
• H. Ichinose, T. Ohye, H. Shinotoh, K. Arai, S. Yamazaki, E. Mizuta, S. Kuno, T. Nagatsu. Biopterin metabolism in patients with malignant syndrome, Parkinsonism and Related Disorders, Vol. 9, No. SUPPL. 1, 2003.  公式リンク  
  
• J. Chen, P. Kuhlencordt, F. Urano, H. Ichinose, J. Astern, P.L. Huang. Effects of chronic treatment with L-arginine on atherosclerosis in ApoE knockout and ApoE/inducible NO synthase double-knockout mice, Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 23, No. 1, pp. 97-103, 2003.  公式リンク  
  
• T.E. Kim, H.S. Lee, Y.B. Lee, S.H. Hong, Y.S. Lee, H. Ichinose, S.U. Kim, M.A. Lee. Sonic hedgehog and FGF8 collaborate to induce dopaminergic phenotypes in the Nurr1-overexpressing neural stem cell, Biochemical and Biophysical Research Communications, Vol. 305, No. 4, pp. 1040-1048, 2003.  公式リンク  
  
• T. Yamakuni, T. Suzuki, H. Inagaki, Y. Ohizumi, T. Nagatsu, H. Ichinose. V-1, a catecholamine biosynthesis regulatory protein, enhances GTP cyclohydrolase I gene transcription in a camp-responsive element dependent manner, Folia Pharmacologica Japonica, Vol. 120, No. SUPPL. 1, 2002.  公式リンク  
  
• T. Suzuki, T. Yamakuni, M. Hagiwara, H. Ichinose. Identification of ATF-2 as a transcriptional regulator for the tyrosine hydroxylase gene, Journal of Biological Chemistry, Vol. 277, No. 43, pp. 40768-40774, 2002.  公式リンク  
  
• A.L. Nielsen, C. Sanchez, H. Ichinose, M. Cerviño, T. Lerouge, P. Chambon, R. Losson. Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1α, EMBO Journal, Vol. 21, No. 21, pp. 5797-5806, 2002.  公式リンク  
  
• M. Ihara, N. Kohara, F. Urano, H. Ichinose, S. Takao, T. Nishida, H. Saiki, Y. Kawamoto, A. Ikeda, S. Takagi, H. Shibasaki. Neuroleptic malignant syndrome with prolonged catatonia in a dopa-responsive dystonia patient, Neurology, Vol. 59, No. 7, pp. 1102-1104, 2002.  公式リンク  
  
• K. Ikemoto, T. Sugimoto, S. Murata, M. Tazawa, T. Nomura, H. Ichinose, T. Nagatsu. (6R)-5,6,7,8-tetrahydro-L-monapterin from Escherichia coli, a novel natural unconjugated tetrahydropterin, Biological Chemistry, Vol. 383, No. 2, pp. 325-330, 2002.  公式リンク  
  
• K. Ikemoto, T. Suzuki, H. Ichinose, T. Ohye, A. Nishimura, K. Nishi, I. Nagatsu, T. Nagatsu. Localization of sepiapterin reductase in the human brain, Brain Research, Vol. 954, No. 2, pp. 237-246, 2002.  公式リンク  
  
• M. Ikeno, H. Inagaki, K. Nagata, M. Morita, H. Ichinose, T. Okazaki. Generation of human artificial chromosomes expressing naturally controlled guanosine triphosphate cyclohydrolase I gene, Genes to Cells, Vol. 7, No. 10, pp. 1021-1032, 2002.  公式リンク  
  
• N. Chen, K. Ikemoto, T. Sugimoto, S. Murata, H. Ichinose, T. Nagatsu. A highly sensitive and specific fdcd method for chirality analysis of naturally occurring pteridines, Heterocycles, Vol. 56, No. 1-2, pp. 387-392, 2002.  公式リンク  
  
• M. Ohtsuki, H. Shiraishi, T. Kato, R. Kuroda, M. Tazawa, C. Sumi-Ichinose, S. Tada, Y. Udagawa, M. Itoh, H. Hishida, H. Ichinose, T. Nagatsu, Y. Hagino, T. Nomura. cAMP inhibits cytokine-induced biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells, Life Sciences, Vol. 70, No. 18, pp. 2187-2198, 2002.  公式リンク  
  
• H. Kawasaki, H. Suemori, K. Mizuseki, K. Watanabe, F. Urano, H. Ichinose, M. Haruta, M. Takahashi, K. Yoshikawa, S.-I. Nishikawa, N. Nakatsuji, Y. Sasai. Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity, Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 3, pp. 1580-1585, 2002.  公式リンク  
  
• M.A. Lee, H.-S. Lee, H.S. Lee, K.G. Cho, B.K. Jin, S. Sohn, Y.S. Lee, H. Ichinose, S.U. Kim. Overexpression of midbrain-specific transcription factor Nurr1 modifies susceptibility of mouse neural stem cells to neurotoxins, Neuroscience Letters, Vol. 333, No. 1, pp. 74-78, 2002.  公式リンク  
  
• S.-I. Muramatsu, A. Kume, M. Matsumura, I. Nagatsu, F. Urano, H. Ichinose, T. Nagatsu, K. Terao, I. Nakano, K. Ozawa, K.-I. Fujimoto, K. Ikeguchi, N. Shizuma, K. Kawasaki, F. Ono, Y. Shen, L. Wang, H. Mizukami. Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes, Human Gene Therapy, Vol. 13, No. 3, pp. 345-354, 2002.  公式リンク  
  
• L. Wang, S. Muramatsu, Y. Lu, K. Ikeguchi, K. Fujimoto, T. Okada, H. Mizukami, Y. Hanazono, A. Kume, F. Urano, H. Ichinose, T. Nagatsu, I. Nakano, K. Ozawa. Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease, Gene Therapy, Vol. 9, No. 6, pp. 381-389, 2002.  公式リンク  
  
• T. Suzuki, H. Inagaki, T. Yamakuni, T. Nagatsu, H. Ichinose. Enhanced expression of GTP cyclohydrolase I in V-1-overexpressing PC12D cells, Biochemical and Biophysical Research Communications, Vol. 293, No. 3, pp. 962-968, 2002.  公式リンク  
  
• H. Ichinose, T. Suzuki, H. Inagaki, T. Ohye, T. Nagatsu. DOPA-responsive dystonia. From causative gene to molecular mechanism., Advances in neurology, Vol. 86, pp. 173-176, 2001.  公式リンク  
  
• M. Mogi, A. Togari, T. Kondo, Y. Mizuno, O. Kogure, S. Kuno, H. Ichinose, T. Nagatsu. Glial cell line-derived neurotrophic factor in the substantia nigra from control and parkinsonian brains, Neuroscience Letters, Vol. 300, No. 3, pp. 179-181, 2001.  公式リンク  
  
• T. Sugimoto, K. Ikemoto, S. Murata, M. Tazawa, T. Nomura, Y. Hagino, H. Ichinose, T. Nagatsu. Identification of (6R)-5,6,7,8-tetrahydro-D-monapterin (=(6R)-2-amino-5,6,7,8-tetrahydro-6-[(1R,2R)-1,2,3 -trihydroxypropyl]-pteridin-4(3H)-one) as the native pteridine in Tetrahymena pyriformis, Helvetica Chimica Acta, Vol. 84, No. 4, pp. 918-927, 2001.  公式リンク  
  
• T. Sugimoto, K. Ikemoto, S. Murata, M. Tazawa, T. Nomura, Y. Hagino, H. Ichinose, T. Nagatsu, A. Wada. A convenient determination of chiral pteridines; application of fluorescence detected circular dichroism (FDCD) to the major pterin from Escherichia coli, Heterocycles, Vol. 54, No. 1, pp. 283-290, 2001.  公式リンク  
  
• C.P. Zabetian, G.M. Anderson, S.G. Buxbaum, R.C. Elston, H. Ichinose, T. Nagatsu, K.-S. Kim, C.-H. Kim, R.T. Malison, J. Gelernter, J.F. Cubells. A quantitative-trait analysis of human plasma-dopamine β-hydroxylase activity: Evidence for a major functional polymorphism at the DBH locus, American Journal of Human Genetics, Vol. 68, No. 2, pp. 515-522, 2001.  公式リンク  
  
• T. Ohye, H. Ichinose, T. Yoshizawa, I. Kanazawa, T. Nagatsu. A new splicing variant for human tyrosine hydroxylase in the adrenal medulla, Neuroscience Letters, Vol. 312, No. 3, pp. 157-160, 2001.  公式リンク  
  
• C. Sumi-Ichinose, F. Urano, R. Kuroda, T. Ohye, M. Kojima, M. Tazawa, H. Shiraishi, Y. Hagino, T. Nagatsu, T. Nomura, H. Ichinose. Catecholamines and serotonin are differently regulated by tetrahydrobiopterin. A study from 6-pyruvoyltetrahydropterin synthase knockout mice, Journal of Biological Chemistry, Vol. 276, No. 44, pp. 41150-41160, 2001.  公式リンク  
  
• H. Ichinose, H. Inagaki, T. Suzuki, T. Ohye, T. Nagatsu. Molecular mechanisms of hereditary progressive dystonia with marked diurnal fluctuation, Segawa's disease, Brain and Development, Vol. 22, No. SUPPL. 1, 2000.  公式リンク  
  
• J.F. Cubells, C.P. Zabetian, G.M. Anderson, H.R. Kranzler, H. Ichinose, T. Nagatsu. Dopamine beta-hydroxylase: Genotype-phenotype relationships, American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 96, No. 4, 2000.  公式リンク  
  
• S. Kaneko, T. Hikida, D. Watanabe, H. Ichinose, T. Nagatsu, R.J. Kreitman, I. Pastan, S. Nakanishi. Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function, Science, Vol. 289, No. 5479, pp. 633-637, 2000.  公式リンク  
  
• M. Mogi, A. Togari, K.-I. Tanaka, N. Ogawa, H. Ichinose, T. Nagatsu. Increase in level of tumor necrosis factor-α in 6-hydroxydopamine- lesioned striatum in rats is suppressed by immunosuppressant FK506, Neuroscience Letters, Vol. 289, No. 3, pp. 165-168, 2000.  公式リンク  
  
• M. Tazawa, M. Ohtsuki, C. Sumi-Ichinose, H. Shiraishi, R. Kuroda, Y. Hagino, S. Nakashima, Y. Nozawa, H. Ichinose, T. Nagatsu, T. Nomura. GTP cyclohydrolase I from Tetrahymena pyriformis: Cloning of cDNA and expression, Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, Vol. 127, No. 1, pp. 65-73, 2000.  公式リンク  
  
• M. Hibiya, H. Ichinose, N. Ozaki, K. Fujita, T. Nishimoto, T. Yoshikawa, Y. Asano, T. Nagatsu. Normal values and age-dependent changes in GTP cyclohydrolase I activity in stimulated mononuclear blood cells measured by high-performance liquid chromatography, Journal of Chromatography B: Biomedical Sciences and Applications, Vol. 740, No. 1, pp. 35-42, 2000.  公式リンク  
  
• T. Maeda, S. Haeno, K. Oda, D. Mori, H. Ichinose, T. Nagatsu, T. Suzuki. Studies on the genotype-phenotype relation in the hph-1 mouse mutant deficient in guanosine triphosphate (GTP) cyclohydrolase I activity, Brain and Development, Vol. 22, No. SUPPL. 1, 2000.  公式リンク  
  
• T. Nagatsu, M. Mogi, H. Ichinose, A. Togari. Cytokines in Parkinson's disease, Journal of Neural Transmission, Supplement, No. 58, pp. 143-151, 2000.  公式リンク  
  
• T. Nagatsu, M. Mogi, H. Ichinose, A. Togari. Changes in cytokines and neurotrophins in Parkinson's disease, Journal of Neural Transmission, Supplement, No. 60, pp. 277-290, 2000.  公式リンク  
  
• Y. Shen, I. Nagatsu, F. Urano, T. Suzuki, H. Ichinose, T. Nagatsu, J. Monahan, I. Nakano, K. Ozawa, S.-I. Muramatsu, K. Ikeguchi, K.-I. Fujimoto, D.-S. Fan, M. Ogawa, H. Mizukami, M. Urabe, A. Kume. Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease, Human Gene Therapy, Vol. 11, No. 11, pp. 1509-1519, 2000.  公式リンク  
  
• H. Ichinose. Segawa's disease, Clinical Neurology, Vol. 40, No. 12, pp. 1284-1286, 2000.  公式リンク  
  
• M. Mogi, A. Togari, T. Kondo, Y. Mizuno, O. Komure, S. Kuno, H. Ichinose, T. Nagatsu. Caspase activities and tumor necrosis factor receptor R1 (p55) level are elevated in the substantia nigra from Parkinsonian brain, Journal of Neural Transmission, Vol. 107, No. 3, pp. 335-341, 2000.  公式リンク  
  
• T. Nagatsu, M. Mogi, H. Ichinose, A. Togari, P. Riederer. Cytokines in Parkinson's disease, NeuroScience News, Vol. 2, No. 3-4, pp. 88-90, 1999.  公式リンク  
  
• T. Nagatsu, H. Ichinose. Regulation of pteridine-requiring enzymes by the cofactor tetrahydrobiopterin, Molecular Neurobiology, Vol. 19, No. 1, pp. 79-96, 1999.  公式リンク  
  
• T. Nagatsu, H. Ichinose. Molecular biology of catecholamine-related enzymes in relation to Parkinson's disease, Cellular and Molecular Neurobiology, Vol. 19, No. 1, pp. 57-66, 1999.  公式リンク  
  
• T. Suzuki, T. Ohye, H. Inagaki, T. Nagatsu, H. Ichinose. Characterization of wild-type and mutants of recombinant human GTP cyclohydrolase I: Relationship to etiology of dopa-responsive dystonia, Journal of Neurochemistry, Vol. 73, No. 6, pp. 2510-2516, 1999.  公式リンク  
  
• I. Nagatsu, K. Ikemoto, K. Kitahama, A. Nishimura, H. Ichinose, T. Nagatsu. Specific localization of the guanosine triphosphate (GTP) cyclohydrolase I-immunoreactivity in the human brain, Journal of Neural Transmission, Vol. 106, No. 7-8, pp. 607-617, 1999.  公式リンク  
  
• M. Mogi, A. Togari, K.-I. Tanaka, N. Ogawa, H. Ichinose, T. Nagatsu. Increase in level of tumor necrosis factor (TNF)-α in 6- hydroxydopamine-lesioned striatum in rats without influence of systemic L- DOPA on the TNF-α induction, Neuroscience Letters, Vol. 268, No. 2, pp. 101-104, 1999.  公式リンク  
  
• M. Mogi, A. Togari, T. Kondo, Y. Mizuno, O. Komure, S. Kuno, H. Ichinose, T. Nagatsu. Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease, Neuroscience Letters, Vol. 270, No. 1, pp. 45-48, 1999.  公式リンク  
  
• C. Itagaki, T. Isobe, M. Taoka, T. Natsume, N. Nomura, T. Horigome, S. Omata, H. Ichinose, T. Nagatsu, L.A. Greene, T. Ichimura. Stimulus-coupled interaction of tyrosine hydroxylase with 14-3-3 proteins, Biochemistry, Vol. 38, No. 47, pp. 15673-15680, 1999.  公式リンク  
  
• H. Inagaki, T. Ohye, T. Suzuki, M. Segawa, Y. Nomura, T. Nagatsu, H. Ichinose. Decrease in GTP cyclohydrolase I gene expression caused by inactivation of one allele in hereditary progressive dystonia with marked diurnal fluctuation, Biochemical and Biophysical Research Communications, Vol. 260, No. 3, pp. 747-751, 1999.  公式リンク  
  
• H. Ichinose, T. Suzuki, H. Inagaki, T. Ohye, T. Nagatsu. Molecular genetics of dopa-responsive dystonia, Biological Chemistry, Vol. 380, No. 12, pp. 1355-1364, 1999.  公式リンク  
  
• H. Ichinose, T. Ohye, T. Suzuki, C. Sumi-Ichinose, T. Nomura, Y. Hagino, T. Nagatsu. Molecular cloning of the human Nurr1 gene: Characterization of the human gene and cDNAs, Gene, Vol. 230, No. 2, pp. 233-239, 1999.  公式リンク  
  
• H. Ichinose, T. Ohye, T. Suzuki, H. Inagaki, T. Nagatsu. The relation between metabolism of biopterin and dystonia-parkinsonism, Japanese Journal of Psychopharmacology, Vol. 19, No. 2, pp. 85-89, 1999.  公式リンク  
  
• H. Ichinose, T. Nagatsu. Molecular genetics of DOPA-responsive dystonia., Advances in neurology, Vol. 80, pp. 195-198, 1999.  公式リンク  
  
• K. Fujimoto, H. Ichinose, T. Nagatsu, T. Nonaka, Y. Mitsui, S. Katoh. Functionally important residues tyrosine-171 and serine-158 in sepiapterin reductase, Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology, Vol. 1431, No. 2, pp. 306-314, 1999.  公式リンク  
  
• T. Nagatsu, H. Ichinose, M. Mogi, A. Togari. Neopterin and cytokines in hereditary dystonia and Parkinson's disease, Pteridines, Vol. 10, No. 1, pp. 5-13, 1999.  公式リンク  
  
• D.-S. Fan, M. Ogawa, K.-I. Fujimoto, K. Ikeguchi, Y. Ogasawara, M. Urabe, M. Nishizawa, I. Nakano, M. Yoshida, I. Nagatsu, H. Ichinose, T. Nagatsu, G.J. Kurtzman, K. Ozawa. Behavioral recovery in 6-hydroxydopamine-lesioned rats by cotransduction of striatum with tyrosine hydroxylase and aromatic L-amino acid decarboxylase genes using two separate adeno-associated virus vectors, Human Gene Therapy, Vol. 9, No. 17, pp. 2527-2535, 1998.  公式リンク  
  
• J. Gelernter, H. Kranzler, J.F. Cubells, H. Ichinose, T. Nagatsu. DRD2 allele frequencies and linkage disequilibria, including the - 141CIns/Del promoter polymorphism, in European-American, African-American, and Japanese subjects, Genomics, Vol. 51, No. 1, pp. 21-26, 1998.  公式リンク  
  
• T. Ohye, T.-A. Hori, S. Katoh, T. Nagatsu, H. Ichinose. Genomic organization and chromosomal localization of the human sepiapterin reductase gene, Biochemical and Biophysical Research Communications, Vol. 251, No. 2, pp. 597-602, 1998.  公式リンク  
  
• T. Nagatsu, H. Ichinose. Genetic basis of dominant dystonia., Advances in pharmacology (San Diego, Calif.), Vol. 42, pp. 44-47, 1998.  公式リンク  
  
• D.-S. Fan, M. Ogawa, K. Ikeguchi, K.-I. Fujimoto, M. Urabe, A. Kume, M. Nishizawa, N. Matsushita, K. Kiuchi, H. Ichinose, T. Nagatsu, G.J. Kurtzman, I. Nakano, K. Ozawa. Prevention of dopaminergic neuron death by adeno-associated virus vector-mediated GDNF gene transfer in rat mesencephalic cells in vitro, Neuroscience Letters, Vol. 248, No. 1, pp. 61-64, 1998.  公式リンク  
  
• T. Nomura, M. Tazawa, M. Ohtsuki, C. Sumi-Ichinose, Y. Hagino, A. Ota, A. Nakashima, K. Mori, T. Sugimoto, O. Ueno, Y. Nozawa, H. Ichinose, T. Nagatsu. Enzymes related to catecholamine biosynthesis in Tetrahymena pyriformis. Presence of GTP cyclohydrolase I, Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, Vol. 120, No. 4, pp. 753-760, 1998.  公式リンク  
  
• T. Nagatsu, H. Ichinose. Molecular biology of hereditary dystonia, No To Hattatsu, Vol. 30, No. 2, pp. 93-100, 1998.  公式リンク  
  
• T. Nagatsu, H. Ichinose. Autosomal dominant DOPA-responsive dystonia caused by mutations in GTP cyclohydrolase I gene, Voprosy Meditsinskoj Khimii, Vol. 44, No. 3, pp. 227-228, 1998.  公式リンク  
  
• H. Ichinose, J.-M. Gamier, P. Chambon, R. Losson. Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2, Gene, Vol. 188, No. 1, pp. 95-100, 1997.  公式リンク  
  
• H. Ichinose, T. Nagatsu. Molecular genetics of DOPA-responsive dystonia (Segawa's disease) - Recent advances, Japanese Journal of Neuropsychopharmacology, Vol. 19, No. 8, pp. 811-815, 1997.  公式リンク  
  
• C. Sumi-Ichinose, H. Ichinose, D. Metzger, P. Chambon. SNF2β-BRG1 is essential for the viability of F9 murine embryonal carcinoma cells, Molecular and Cellular Biology, Vol. 17, No. 10, pp. 5976-5986, 1997.  公式リンク  
  
• H. Ichinose, T. Nagatsu. Molecular genetics of hereditary dystonia - Mutations in the GTP cyclohydrolase I gene, Brain Research Bulletin, Vol. 43, No. 1, pp. 35-38, 1997.  公式リンク  
  
• T. Nagatsu, H. Ichinose. Molecular biology of catecholamine neurons in relation to Parkinson's disease., Advances in neurology, Vol. 69, pp. 147-152, 1996.  公式リンク  
  
• T. Nagatsu, H. Ichinose. GTP cyclohydrolase I gene, tetrahydrobiopterin, and tyrosine hydroxylase gene: Their relations to dystonia and parkinsonism, Neurochemical Research, Vol. 21, No. 2, pp. 245-250, 1996.  公式リンク  
  
• T. Nagatsu, H. Ichinose, T. Ohye. Molecular aspects of the dopaminergic neurotoxins in relation to tyrosine hydroxylase isoforms, Biogenic Amines, Vol. 12, No. 2, pp. 117-123, 1996.  公式リンク  
  
• S. Haeno, T. Maeda, M. Abe, K. Oda, T. Suzuki, H. Ichinose, T. Nagatsu. Molecular genetic and metabolic aspects of hph-1,a mouse mutant deficient in gtp cyclohydrolase i activity, Japanese Journal of Human Genetics, Vol. 41, No. 1, 1996.  公式リンク  
  
• B. LeDouarin, A. L. Nielsen, J. M. Garnier, H. Ichinose, F. Jeanmougin, R. Losson, P. Chambon. A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors, Embo Journal, Vol. 15, No. 23, pp. 6701-6715, 1996.  公式リンク  
  
• H. Ichinose, T. Nagatsu. Molecular genetics of hereditary progressive dystonia (HPD/Segawa's disease), Nippon rinsho. Japanese journal of clinical medicine, Vol. 54, No. 5, pp. 1453-1459, 1996.  公式リンク  
  
• I. Nagatsu, H. Ichinose, M. Sakai, K. Titani, M. Suzuki, T. Nagatsu. Immunocytochemical localization of GTP cyclohydrolase I in the brain, adrenal gland, and liver of mice, Journal of Neural Transmission, Vol. 102, No. 3, pp. 175-188, 1995.  公式リンク  
  
• C. Sumi-Ichinose, S. Hasegawa, H. Ichinose, H. Sawada, K. Kobayashi, M. Sakai, T. Fujii, H. Nomura, T. Nomura, I. Nagatsu, Y. Hagino, K. Fujita, T. Nagatsu. Analysis of the alternative promoters that regulate tissue-specific expression of human aromatic L-amino acid decarboxylase, Journal of Neurochemistry, Vol. 64, No. 2, pp. 514-524, 1995.  公式リンク  
  
• H. Ichinose, N. Blau, R. Matalon, T. Nagatsu. Genomic organization of mouse and human GTP cyclohydrolase I genes and mutations found in the human gene, Pteridines, Vol. 6, No. 3, pp. 104-107, 1995.  公式リンク  
  
• H. Ichinose, T. Nagatsu. GTP cyclohydrolase I gene and hereditary dystonia, Japanese Journal of Neuropsychopharmacology, Vol. 17, No. 8, pp. 517-524, 1995.  公式リンク  
  
• N. Blau, H. Ichinose, T. Nagatsu, C.W. Heizmann, F. Zacchello, A.B. Burlina. A missense mutation in a patient with guanosine triphosphate cyclohydrolase I deficiency missed in the newborn screening program, The Journal of Pediatrics, Vol. 126, No. 3, pp. 401-405, 1995.  公式リンク  
  
• A. Ota, H. Ichinose, T. Nagatsu. Mouse sepiapterin reductase: an enzyme involved in the final step of tetrahydrobiopterin biosynthesis. Primary structure deduced from the cDNA sequence, BBA - Gene Structure and Expression, Vol. 1260, No. 3, pp. 320-322, 1995.  公式リンク  
  
• T. Ohye, H. Ichinose, M. Ogawa, M. Yoshida, T. Nagatsu. Alterations in multiple tyrosine hydroxylase mRNAs in the substantia nigra, locus coeruleus and adrenal gland of MPTP-treated parkinsonian monkeys, Neurodegeneration, Vol. 4, No. 1, pp. 81-85, 1995.  公式リンク  
  
• H. Ichinose, T. Ohye, Y. Matsuda, T.-A. Hori, N. Blau, A. Burlina, B. Rouse, R. Matalon, K. Fujita, T. Nagatsu. Characterization of mouse and human GTP cyclohydrolase I genes: Mutations in patients with GTP cyclohydrolase I deficiency, Journal of Biological Chemistry, Vol. 270, No. 17, pp. 10062-10071, 1995.  公式リンク  
  
• T. Nomura, M. Ohtsuki, S. Matsui, C. Sumi-Ichinose, H. Nomura, Y. Hagino, K. Iwase, H. Ichinose, K. Fujita, T. Nagatsu. Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma, Journal of Neural Transmission - General Section, Vol. 101, No. 1-3, pp. 237-242, 1995.  公式リンク  
  
• H. Ichinose, T. Ohye, M. Segawa, Y. Nomura, K. Endo, H. Tanaka, S. Tsuji, K. Fujita, T. Nagatsu. GTP cyclohydrolase I gene in hereditary progressive dystonia with marked diurnal fluctuation, Neuroscience Letters, Vol. 196, No. 1-2, pp. 5-8, 1995.  公式リンク  
  
• H. Ichinose, T. Ohye, M. Yokochi, K. Fujit, T. Nagatsu. GTP cyclohydrolase I activity in mononuclear blood cells in juvenile parkinsonism, Neuroscience Letters, Vol. 190, No. 2, pp. 140-142, 1995.  公式リンク  
  
• H. Ichinose, T. Ohye, E.-I. Takahashi, N. Seki, T.-A. Hori, M. Segawa, Y. Nomura, K. Endo, H. Tanaka, S. Tsuji, K. Fujita, T. Nagatsu. Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene, Nature Genetics, Vol. 8, No. 3, pp. 236-242, 1994.  公式リンク  
  
• A. Ota, H. Ichinose, K. Kobayashi, S. Morita, H. Sawada, T. Mizuguchi, T. Nagatsu. Nicotine-induced regulation of tyrosine hydroxylase activity in adrenal gland of transgenic mouse carrying human tyrosine hydroxylase gene, Neuroscience Letters, Vol. 166, No. 1, pp. 55-58, 1994.  公式リンク  
  
• S. Nasrin, H. Ichinose, H. Hidaka, T. Nagatsu. Recombinant human tyrosine hydroxylase types 1-4 show regulatory kinetic properties for the natural (6R)-tetrahydrobiopterin cofactor, Journal of Biochemistry, Vol. 116, No. 2, pp. 393-398, 1994.  公式リンク  
  
• H. Ichinose, T. Ohye, K. Fujita, F. Pantucek, K. Lange, P. Riederer, T. Nagatsu. Quantification of mRNA of tyrosine hydroxylase and aromatic L-amino acid decarboxylase in the substantia nigra in Parkinson's disease and schizophrenia, Journal of Neural Transmission - Parkinson's Disease and Dementia Section, Vol. 8, No. 1-2, pp. 149-158, 1994.  公式リンク  
  
• T. Terasaki, Y. Matsuno, Y. Shimosato, K. Yamaguchi, H. Ichinose, T. Nagatsu, K. Kato. Establishment of a human small cell lung cancer cell line producing a large amount of anti-diuretic hormone, Japanese Journal of Cancer Research, Vol. 85, No. 7, pp. 718-722, 1994.  公式リンク  
  
• T. Fujiwara, T. Motoyama, N. Ishihara, H. Watanabe, T. Kumanishi, K. Kato, H. Ichinose, T. Nagatsu. Characterization of four new cell lines derived from small-cell gastrointestinal carcinoma, International Journal of Cancer, Vol. 54, No. 6, pp. 965-971, 1993.  公式リンク  
  
• H. Ichinose, T. Nagatsu. Molecular genetics of aromatic L-amino acid decarboxylase, Japanese Journal of Psychopharmacology, Vol. 13, No. 4, pp. 251-256, 1993.  公式リンク  
  
• T. Nomura, H. Ichinose, C. Sumi-Ichinose, H. Nomura, Y. Hagino, K. Fujita, T. Nagatsu. Cloning and sequencing of cDNA encoding mouse GTP cyclohydrolase I, Biochemical and Biophysical Research Communications, Vol. 191, No. 2, pp. 523-527, 1993.  公式リンク  
  
• H. Ichinose, T. Ohye, K. Fujita, M. Yoshida, S. Ueda, T. Nagatsu. Increased heterogeneity of tyrosine hydroxylase in humans, Biochemical and Biophysical Research Communications, Vol. 195, No. 1, pp. 158-165, 1993.  公式リンク  
  
• T. Nagatsu, H. Ichinose, S. Katoh, K. Fujita, K. Titani. 6R-tetrahydrobiopterin biosynthesis: structures of rat and human sepiapterin reductase., Journal of Nutritional Science and Vitaminology, Vol. Spec No, pp. 510-513, 1992.  公式リンク  
  
• A. Togari, H. Ichinose, S. Matsumoto, K. Fujita, T. Nagatsu. Multiple mRNA forms of human GTP cyclohydrolase I, Biochemical and Biophysical Research Communications, Vol. 187, No. 1, pp. 359-365, 1992.  公式リンク  
  
• C. Sumi-Ichinose, H. Ichinose, E.-I. Takahashi, T.-A. Hori, T. Nagatsu. Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and serotonin biosynthesis, Biochemistry, Vol. 31, No. 8, pp. 2229-2238, 1992.  公式リンク  
  
• H. Ichinose, C. Sumi-Ichinose, T. Ohye, Y. Hagino, K. Fujita, T. Nagatsu. Tissue-specific alternative splicing of the first exon generates two types of mRNAs in human aromatic L-amino acid decarboxylase, Biochemistry, Vol. 31, No. 46, pp. 11546-11550, 1992.  公式リンク  
  
• H. Ichinose, S. Katoh, T. Sueoka, K. Titani, K. Fujita, T. Nagatsu. Cloning and sequencing of cDNA encoding human sepiapterin reductase, Pteridines, Vol. 3, No. 1-2, pp. 41-42, 1992.  公式リンク  
  
• S. Nasrin, H. Ichinose, T. Nagatsu. Comparison of characteristics of bovine aromatic l-amino acid decarboxylase with human enzyme, Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular, Vol. 1118, No. 3, pp. 318-322, 1992.  公式リンク  
  
• H. Ichinose, S. Katoh, T. Sueoka, K. Titani, K. Fujita, T. Nagatsu. Cloning and sequencing of cDNA encoding human sepiapterin reductase. An enzyme involved in tetrahydrobiopterin biosynthesis, Biochemical and Biophysical Research Communications, Vol. 179, No. 1, pp. 183-189, 1991.  公式リンク  
  
• C. Sumi, H. Ichinose, T. Nagatsu. Characterization of recombinant human aromatic l-amino acid decarboxylase expressed in COS cells, Journal of Neurochemistry, Vol. 55, No. 3, pp. 1075-1078, 1990.  公式リンク  
  
• R. Oyama, S. Katoh, T. Sueoka, M. Suzuki, H. Ichinose, T. Nagatsu, K. Titani. The complete amino acid sequence of the mature form of rat sepiapterin reductase, Biochemical and Biophysical Research Communications, Vol. 173, No. 2, pp. 627-631, 1990.  公式リンク  
  
• S. Ichikawa, H. Ichinose, T. Nagatsu. Multiple mRNAs of monkey tyrosine hydroxylase, Biochemical and Biophysical Research Communications, Vol. 173, No. 3, pp. 1331-1336, 1990.  公式リンク  
  
• H. Ichinose, Y. Kurosawa, K. Titani, K. Fujita, T. Nagatsu. Isolation and characterization of a cDNA clone encoding human aromatic L-amino acid decarboxylase, Biochemical and Biophysical Research Communications, Vol. 164, No. 3, pp. 1024-1030, 1989.  公式リンク  
  
• M. Naoi, T. Takahashi, H. Ichinose, K. Wakabayashi, T. Sugimura, T. Nagatsu. Uptake of heterocyclic amines, Trp-P-1 and Trp-P-2, into clonal rat pheochromocytoma PC12h cells by dopamine uptake system, Neuroscience Letters, Vol. 99, No. 3, pp. 317-322, 1989.  公式リンク  
  
• I. Nagatsu, S. Furune, H. Ichinose, M. Spatz, T. Nagatsu. Quantitative analysis of reduction of aromatic-L-aminoacid decarboxylase- and tyrosine hydroxylase-like immunoreactivities in the nigrostriatal dopaminergic neurons of MPTP-treated mice, Biogenic Amines, Vol. 6, No. 3, pp. 263-277, 1989.  公式リンク  
  
• M. Naoi, T. Takahashi, H. Ichinose, K. Wakabayashi, T. Sugimura, T. Nagatsu. Reduction of enzyme activity of tyrosine hydroxylase and aromatic L-aminoacid decarboxylase in clonal pheochromocytoma PC12h cells by carcinogenic heterocyclic amines, Biochemical and Biophysical Research Communications, Vol. 157, No. 2, pp. 494-499, 1988.  公式リンク  
  
• M. Naoi, H. Ichinose, T. Takahashi, I. Nagatsu, T. Nagatsu. Reduction of aromatic l-amino acid decarboxylase activity in clonal pheochromocytoma PC12h cells by culture in the presence of N-methyl-4-phenylpyridinium ion (MPP+), Neuroscience Letters, Vol. 95, No. 1-3, pp. 229-235, 1988.  公式リンク  
  
• K. Kobayashi, N. Kaneda, H. Ichinose, F. Kishi, A. Nakazawa, Y. Kurosawa, K. Fujita, T. Nagatsu. Structure of the human tyrosine hydroxylase gene: Alternative splicing from a single gene accounts for generation of four mRNA types, Journal of Biochemistry, Vol. 103, No. 6, pp. 907-912, 1988.  公式リンク  
  
• M. Naoi, T. Takahashi, H. Ichinose, T. Nagatsu. Inhibition of aromatic L-aminoacid decarboxylase in clonal pheochromocytoma PC12h cells by N-methyl-4-phenylpyridinium ion (MPP+), Biochemical and Biophysical Research Communications, Vol. 152, No. 1, pp. 15-21, 1988.  公式リンク  
  
• A. Togari, H. Ichinose, K. Kojima, Y. Hirata, T. Nagatsu. Centrally mediated activation of tyrosine hydroxylation in rat adrenals by thyrotropin-releasing hormone, Biochemical Pharmacology, Vol. 37, No. 8, pp. 1637-1639, 1988.  公式リンク  
  
• I. Nishigaki, H. Ichinose, K. Tamai, T. Nagatsu. Purification of aromatic L-amino acid decarboxylase from bovine brain with a monoclonal antibody., Biochemical Journal, Vol. 252, No. 2, pp. 331-335, 1988.  公式リンク  
  
• N. Kaneda, H. Ichinose, K. Kobayashi, K. Oka, F. Kishi, A. Nakazawa, Y. Kurosawa, K. Fujita, T. Nagatsu. Molecular cloning of cDNA and chromosomal assignment of the gene for human phenylethanolamine N-methyltransferase, the enzyme for epinephrine biosynthesis, Journal of Biological Chemistry, Vol. 263, No. 16, pp. 7672-7677, 1988.  公式リンク  
  
• M. Naoi, H. Ichinose, T. Takahashi, T. Nagatsu. Sensitive assay for determination of pyridoxal-5-phosphate in enzymes using high-performance liquid chromatography after derivatization with cyanide, Journal of Chromatography B: Biomedical Sciences and Applications, Vol. 434, No. C, pp. 209-214, 1988.  公式リンク  
  
• H. Ichinose, A. Togari, H. Suzuki, H. Kumagai, T. Nagatsu. Increase of catecholamines in mouse brain by systemic administration of gamma-glutamyl L-3,4-dihydroxyphenylalanine., Journal of Neurochemistry, Vol. 49, No. 3, pp. 928-932, 1987.  公式リンク  
  
• N. Kaneda, K. Kobayashi, H. Ichinose, F. Kishi, A. Nakazawa, Y. Kurosawa, K. Fujita, T. Nagatsu. Isolation of a novel cDNA clone for human tyrosine hydroxylase: Alternative RNA splicing produces four kinds of mRNA from a single gene, Biochemical and Biophysical Research Communications, Vol. 146, No. 3, pp. 971-975, 1987.  公式リンク  
  
• K. Kobayashi, N. Kaneda, H. Ichinose, F. Kishi, A. Nakazawa, Y. Kurosawa, K. Fujita, T. Nagatsu. Isolation of a full-length cDNA clone encoding human tyrosine hydroxylase type 3, Nucleic Acids Research, Vol. 15, No. 16, 1987.  公式リンク  
  
• T. Terasaki, Y. Shimosato, T. Nakajima, M. Tsumuraya, H. Ichinose, T. Nagatsu, K. Kato. Reversible squamous cell characteristics induced by vitamin A deficiency in a small cell lung cancer cell line, Cancer Research, Vol. 47, No. 13, pp. 3533-3537, 1987.  公式リンク  
  
• T. Terasaki, Y. Shimosato, T. Nakajima, M. Tsumuraya, S. Morinaga, S. Hirohashi, K. Yamaguchi, K. Kato, H. Ichinose, T. Nagatsu. CHANGES IN CELL CHARACTERISTICS DUE TO CULTURE CONDITIONS IN CELL-LINES FROM HUMAN SMALL-CELL LUNG-CANCER, Japanese Journal of Clinical Oncology, Vol. 16, No. 3, pp. 203-212, 1986.  公式リンク  
  
• T. Nakajima, Y. Shimosato, S. Morinaga, T. Terasaki, M. Tsumuraya, K. Yamaguchi, H. Ichinose, T. Nagatsu, K. Kato, Y. Nakazato. Immunohistochemical study of small cell lung carcinoma; with special reference to the neuroendocrine markers aromatic L-amino acid decarboxylase and gastrin-releasing peptide, Japanese Journal of Clinical Oncology, Vol. 16, No. 3, pp. 223-233, 1986.  公式リンク  
  
• T. Nagatsu, H. Ichinose, K. Kojima, T. Kameya, J. Shimase, T. Kodama, Y. Shimosato. Aromatic l-amino acid decarboxylase activities in human lung tissues: Comparison between normal lung and lung carcinomas, Biochemical medicine, Vol. 34, No. 1, pp. 52-59, 1985.  公式リンク  
  
• H. Ichinose, K. Kojima, A. Togari, Y. Kato, S. Parvez, H. Parvez, T. Nagatsu. Simple purification of aromatic l-amino acid decarboxylase from human pheochromocytoma using high-performance liquid chromatography, Analytical Biochemistry, Vol. 150, No. 2, pp. 408-414, 1985.  公式リンク  
  
• T. Terasaki, T. Kameya, T. Nakajima, M. Tsumuraya, Y. Shimosato, K. Kato, H. Ichinose, T. Nagatsu, T. Hasegawa. Interconversion of biological characteristics of small cell lung cancer depending on culture conditions, Gann, The Japanese Journal of Cancer Research, Vol. 75, No. 12, pp. 1089-1099, 1984.  公式リンク  
  

国際会議発表 (査読有り)

• H. Ichinose, D. Homma, C. Sumi-Ichinose, T. Nomura, K. Kondo. GTP cyclohydrolase regulation. Implications for brain development and function., Advances in Pharmacology, Vol. 68, pp. 23-35, 2013.  公式リンク  
  
• Ichiro Kawahata, Hiroshi Ichinose. Phosphorylated tyrosine hydroxylase formed insoluble aggregates by inhibition of ubiquitin proteasome system in NGF-differentiated PC12D cells, 14th International Symposium on Pteridines and Folates, Pteridines, Vol. 20, No. 3, pp. 82-83, 2009.
• Hiroshi Ichinose, Chiho Ichinose, Ichiro Kawahata, Takahide Nomura. Regulation of dopaminergic neural transmission by the amount of the TH protein at nerve terminals, Journal of Phamacological Sciences, Vol. 109, Supplement 1, p. 32, 2009.
• Ichiro Kawahata, Saburo Yagishita, Kazuko Hasegawa, Ikuko Nagatsu, Toshiharu Nagatsu, Hiroshi Ichinose. Formation of insoluble aggregates of phosphorylated tyrosine hydroxylase after proteasomal inhibition in PC12D cells, 12th International Congress of Parkinson's Disease and Movement Disorders, Movement Disorders, Wiley-Blackwell, Vol. 23, p. S15, Nov. 2008.  公式リンク  
  
• Hiroshi Ichinose, Ichiro Kawahata, Wataru Sato, Kazuaki Mizuno, Yoshiro Kurabayashi, Itaru Toyoshima, Saburo Yagishita, Kazuko Hasegawa. Developmental Alterations of LRRK2 in the Mouse Brain, 12th International Congress of Parkinson's Disease and Movement Disorders, Movement Disorders, Wiley-Blackwell, Vol. 23, p. S21, Nov. 2008.
• H. Ichinose, T. Nagatsu, C. Sumi-Ichinose, T. Nomura. Dopa-Responsive Dystonia, Genetics of Movement Disorders, pp. 419-428, 2003.  公式リンク  
  
• T. Nagatsu, H. Ichinose. Genetic Basis of Dominant Dystonia, Advances in Pharmacology, Vol. 42, pp. 44-47, 1997.  公式リンク  
  
• T. Nagatsu, K. Kobayashi, H. Ichinose. Alterations in catecholamine system enzymes, Annals of the New York Academy of Sciences, Vol. 771, pp. 159-165, 1995.  公式リンク  
  

国内会議発表 (査読有り)

• Haruka Kono, Satoshi Hara, Tadaomi Furuta, Hiroshi Ichinose. Analysis of the binding profile of quinonoid-form of dihydropteridine to quinonoid-dihydropteridine reductase, CBI Annual Meeting 2023, Oct. 2023.
• 一瀬宏, 川畑伊知郎. プロテアゾーム阻害によるリン酸化チロシン水酸化酵素の不溶性凝集体形成と生理的意義, 第413回研究協議会研究発表会, ビタミン, 日本ビタミン学会, Vol. 82, No. 11, pp. 624-625, Nov. 2009.
• Ichiro Kawahata, Hiroshi Ichinose. Long-term up-regulation of the level of phosphorylated tyrosine hydroxylase by depletion of dopamine or biopterin, 32nd Annual Meeting of the Japan Neuroscience Society (Neuro 2009), Neuroscience Research, Vol. 65, Supplement 1, Page S66 (O3-G3-1), 2009.
• Ichiro Kawahata, Saburo Yagishita, Kazuko Hasegawa, Ikuko Nagatsu, Toshiharu Nagatsu, Hiroshi Ichinose. Formation of insoluble aggregates of phosphorylated tyrosine hydroxylase after proteasomal inhibition in PC12D cells, 31st Annual Meeting of the Japan Neuroscience Society (Neuro 2008), Neuroscience Research, Volume 61, No. 1, S123, 2008.
• 川畑伊知郎, 一瀬 宏. リン酸化されたチロシン水酸化酵素のユビキチン プロテアソーム系による分解とその凝集特性, 生化学, Page 3T23-8, 2008.

国際会議発表 (査読なし・不明)

• Hoshino, K., Kimura, K., Hayashi, M., Nagao, Y., Hachimori, K., Terao, Y., Kawahata, I., Shintaku, H., Hiroshi Ichinose. Gene analysis of Segawa disease at the neurological clinic for children, 23rd World Congress of Neurology (WCN), JOURNAL OF THE NEUROLOGICAL SCIENCES, ELSEVIER SCIENCE BV, Vol. 381, pp. 126-126, Oct. 2017.
• Kawahata, I., Lai, Y., Morita, J., Kato, S., Ohtaku, S., Tomioka, Y., Tabuchi, A., Tsuda, M., Sumi-Ichinose, C., Kondo, K., Izumi, Y., Kume, T., Akaike, A., Ohashi, K., Mizuno, K., Hasegawa, K., Hiroshi Ichinose, Kobayashi, K., Yamakuni, T.. V-1/CP complex formation is required for genetic co-regulation of adult nigrostriatal dopaminergic function via the RHO/MAL/SRF pathway in vitro and in vivo, 23rd World Congress of Neurology (WCN), JOURNAL OF THE NEUROLOGICAL SCIENCES, ELSEVIER SCIENCE BV, Vol. 381, pp. 359-360, Oct. 2017.
• Amagase, Harunobu, Hiroshi Ichinose, Kondo, Atsuo, Abe, Koichi, Watanabe, Toshiaki, Sueki, Kazuo, Shigeoka, Shigeru. Continuous Efforts of the Vitamin Society of Japan to Increase Folate Intake in Japan, Experimental Biology Meeting, FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, Vol. 30, Apr. 2016.
• Abe, J., Nishikomori, R., Izawa, K., Kawai, T., Yasumi, T., Mitsuiki, N., Ohara, O., Toyoshima, I., Hasegawa, K., Hiroshi Ichinose, Heike, T.. GENETIC ANALYSIS OF AICARDI-GOUTIERES SYNDROME IN JAPAN, 15th Biennial Meeting European-Society-for-Immunodeficiency (ESID), JOURNAL OF CLINICAL IMMUNOLOGY, SPRINGER/PLENUM PUBLISHERS, Vol. 32, pp. 63-63, Sept. 2012.
• Ichiro Kawahata, Saburo Yagishita, Kazuko Hasegawa, Ikuko Nagatsu, Toshiharu Nagatsu, Hiroshi Ichinose. Dopamine-synthesizing enzymes formed intracellular inclusions after proteasomal inhibition in PC12D cells, 3rd International Symposium on Dopaminergic and Nondopaminergic Mechanisms in Parkinson's Disease, Progress in Medicine, Life Science, Vol. 28, No. 3, p. 876, Mar. 2008.  公式リンク  
  

国内会議発表 (査読なし・不明)

• 河野はるか, 原怜, 古田忠臣, 一瀬宏. 葉酸代謝とビオプテリン代謝の接点, 第472回ビタミンB研究協議会, Sept. 2023.
• 河野はるか, 原怜, 古田忠臣, 一瀬宏. 分子シミュレーションによるキノノイドジヒドロプテリジン還元酵素の基質認識機構の解析, 2019年度日本生化学会関東支部例会, June 2019.
• 河野はるか, 古田忠臣, 原怜, 一瀬宏. キノノイドジヒドロプテリジン還元酵素の基質認識機構の解析, 日本ビタミン学会第71回大会, June 2019.
• 一瀬宏. パーキンソン病患者脳脊髄液におけるプテリジン化合物の変化について, 第449回ビタミンB研究協議会, Sept. 2017.
• 一瀬宏, 黒崎宏貴, 荒川志信, 渡邊祐貴, 長谷川一子, 横山照夫, 堀内恵美子, Jan O. Aasly. 遺伝性パーキンソン病Park8患者家系における脳脊髄液中ビオプテリン代謝の解析, 第446回ビタミンB研究協議会, ビタミン, Vol. 91, No. 2, p. 153, Feb. 2017.
• 一瀬宏. 8.フェニルケトン尿症における認知機能障害のメカニズム(第442回研究協議会研究発表要旨,ビタミンB研究委員会), ビタミン, 公益社団法人 日本ビタミン学会, Vol. 90, No. 1, pp. 46-47, 2016.
• 一瀬宏. 6. ビオプテリンの生理機能と代謝に関する新しい知見(ビタミン・バイオファクターの生理機能に関する最新の話題,シンポジウム(平成26年度),ビタミンB研究委員会), ビタミン, 公益社団法人 日本ビタミン学会, Vol. 89, No. 5, pp. 294-295, 2015.
• 徐 峰, 嶋口 翔, 実近 翔, 本田 俊一郎, 中田 理恵子, 一瀬宏. 8.ビオプテリン代謝と葉酸代謝の接点について(第435回研究協議会研究発表要旨,ビタミンB研究委員会), ビタミン, 公益社団法人 日本ビタミン学会, Vol. 88, No. 5, pp. 311, 2014.
• 一瀬宏, 本間 大悟, 一瀬 鷲見 千穂, 近藤 一直. モノアミン・ビオプテリン代謝改変マウスを用いたモノアミンニューロンの制御機構と発達変化の解析, 自律神経 = The Autonomic nervous system, Vol. 50, No. 1, pp. 16-17, Mar. 2013.
• 一瀬宏. ビオプテリンの生理機能と病態代謝(学会賞受賞講演,第65回大会講演要旨), ビタミン, 公益社団法人 日本ビタミン学会, Vol. 87, No. 4, pp. 180-181, 2013.
• 一瀬宏, 岩下 由佳, 宗実 悠佳, 徳岡 宏文, 村松 慎一. 7.チロシン水酸化酵素過剰発現による神経終末でのドーパミン量への影響(第431回研究協議会研究発表要旨,ビタミンB研究委員会), ビタミン, 公益社団法人 日本ビタミン学会, Vol. 87, No. 5, pp. 289-290, 2013.
• Lai, Yanxin, Jin, Jingmei, Kawahata, Ichiro, Morita, Junichi, Fukunaga, Kohji, Hiroshi Ichinose, Yamakuni, Tohru. A novel regulatory mechanism of tyrosine hydroxylase gene expression via a new actin cytoskeleton formation enhancer (V-1)/DLK 1/notch 1-mediated signaling in murine adrenal chromaffin cells, 85th Annual Meeting of the Japanese-Pharmacological-Society, JOURNAL OF PHARMACOLOGICAL SCIENCES, JAPANESE PHARMACOLOGICAL SOC, Vol. 118, pp. 166P-166P, 2012.
• Kawahata, Ichiro, Morita, Junichi, Tabuchi, Akiko, Tsuda, Masaaki, Hiroshi Ichinose, Izumi, Yasuhiko, Kume, Toshiaki, Akaike, Akinori, Yamakuni, Tohru. V-1 regulates tyrosine hydroxylase gene expression via SRF-mediated transcription coupled with actin polymerization, 85th Annual Meeting of the Japanese-Pharmacological-Society, JOURNAL OF PHARMACOLOGICAL SCIENCES, JAPANESE PHARMACOLOGICAL SOC, Vol. 118, pp. 61P-61P, 2012.
• 一瀬宏, 徐 峰, 原 慶賢, 嶋口 翔, 実近 翔. 7.ビオプテリン量調節における再還元反応の寄与について(第429回研究協議会研究発表要旨,ビタミンB研究委員会), ビタミン, 公益社団法人 日本ビタミン学会, Vol. 86, No. 11, pp. 655, 2012.
• Chiken, Satomi, Sumi-Ichinose, Chiho, Hiroshi Ichinose, Kondo, Kazunao, Nambu, Atsushi. Neuronal activity of the basal ganglia in a transgenic mouse model of dopa-responsive dystonia, 34th Annual Meeting of the Japan Neuroscience Society (Neuro 2011), NEUROSCIENCE RESEARCH, ELSEVIER IRELAND LTD, Vol. 71, pp. E142-E142, 2011.
• Ohkuma, Mahito, Kawai, Fusao, Horiguchi, Masayuki, Hiroshi Ichinose, Miyachi, Ei-ichi. A type of the human retinal bipolar cell expresses the type II sodium channel, 34th Annual Meeting of the Japan Neuroscience Society (Neuro 2011), NEUROSCIENCE RESEARCH, ELSEVIER IRELAND LTD, Vol. 71, pp. E147-E147, 2011.
• Tokuoka, Hirofumi, Muramatsu, Shin-ichi, Ichinose, Chiho, Metzger, Daniel, Hiroshi Ichinose. Trans-axonal compensation of dopamine in the nigrostriatal dopaminergic projection, 34th Annual Meeting of the Japan Neuroscience Society (Neuro 2011), NEUROSCIENCE RESEARCH, ELSEVIER IRELAND LTD, Vol. 71, pp. E140-E141, 2011.
• Hatanaka, Takayuki, Hatanaka, Yasuhito, Ito, Takehito, Igarashi, Hiroyuki, Tokuoka, Hirofumi, Muramatsu, Shin-ichi, Endo, Tsuyoshi, Hirosaki, Ken, Takasaki, Akihiko, nobuhiro hayashi, Metzger, Daniel, Hiroshi Ichinose. Generation of transgenic mice to analyze the role of Nurr1 and Nur77 genes in the adult brain, 34th Annual Meeting of the Japan Neuroscience Society (Neuro 2011), NEUROSCIENCE RESEARCH, ELSEVIER IRELAND LTD, Vol. 71, pp. E213-E214, 2011.
• 堀口 美恵子, 福田 早苗, 一瀬宏, 中富 康仁, 山口 浩二, 倉恒 弘彦, 渡辺 恭良. 10.慢性疲労症候群患者におけるGTPシクロヒドロラーゼI遺伝子多型の解析(第425回研究協議会研究発表要旨,ビタミンB研究委員会), ビタミン, 公益社団法人 日本ビタミン学会, Vol. 85, No. 11, pp. 616, 2011.
• 一瀬宏, 本間 大悟, 徳岡 宏文, 加藤 節子. 2.ビオプテリン欠乏マウスにおける生後発達期におけるモノアミンの変化(第420回研究協議会研究発表要旨,ビタミンB研究委員会), ビタミン, 公益社団法人 日本ビタミン学会, Vol. 84, No. 8, pp. 396-397, 2010.
• 一瀬宏, 実近 翔, 須藤 雄介. 10.ジヒドロプテリジン還元酵素ノックアウトマウスにおけるモノアミン代謝の変化(第418回研究協議会研究発表要旨,ビタミンB研究委員会), ビタミン, 公益社団法人 日本ビタミン学会, Vol. 84, No. 2, pp. 87-88, 2010.
• Homma, Daigo, Tokuoka, Hirofumi, Katoh, Setsuko, Hiroshi Ichinose. Alterations in the monoamines and the synthesizing enzymes in the postnatal developmental period of the brain of Spr(-/-) mice, 33rd Annual Meeting of the Japan Neuroscience Society (Neuro 2010), NEUROSCIENCE RESEARCH, ELSEVIER IRELAND LTD, Vol. 68, pp. E82-E82, 2010.
• Tokuoka, Hirofumi, Muramatsu, Shin-ichi, Hiroshi Ichinose. Compenensatory regulation of dopamine content in the nigro-striatal dopaminergic projection, 33rd Annual Meeting of the Japan Neuroscience Society (Neuro 2010), NEUROSCIENCE RESEARCH, ELSEVIER IRELAND LTD, Vol. 68, pp. E55-E56, 2010.

その他の論文・著書など

• 西小森 隆太, 阿部 純也, 井澤 和司, 河合 朋樹, 八角 高裕, 満生 紀子, 小原 收, 豊島 至, 長谷川 一子, 一瀬宏, 平家 俊男. P1-004  本邦におけるAicardi-Goutières症候群の遺伝子解析, 日本臨床免疫学会会誌, The Japan Society for Clinical Immunology, Vol. 35, No. 4, pp. 328b-328b, 2012.

特許など

• 一瀬宏, 原怜, 吉田　勇輝, 村松　慎一, 加藤　節子. ＳＰＲをコードするポリヌクレオチドを含む組み換えベクター、及びそれを含む組成物. 特許. 公開. 国立大学法人東京工業大学, 学校法人自治医科大学, 加藤　節子. 2018/11/01. 特願2018-206643. 2020/05/07. 特開2020-068734. 2020.

学位論文

• Effects of Heterocyclic Amines in Food on Dopamine Metabolism in Nigro-striatal Dopaminergic Neurons. ,  本文,  Doctor of Medicine,  Nagoya University,  1989/--/--, 

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